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VItamin C in Thermal injuRY: The VICToRY Trial
Clinical Evaluation Research Unit at Kingston General Hospital
Shock
Thermal Burn
This study aims to show that giving high dose, intravenous vitamin C in addition to
standard care to burned critically ill patients will be associated with less organ
dysfunction, improved survival and a quicker rate of recovery. In this study, all
patients will receive standard care and of the pat1 expand
This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery. In this study, all patients will receive standard care and of the patients will also receive high dose intravenous vitamin C, while the other half of patients will receive placebo. Type: Interventional Start Date: Jul 2020 |
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpressi1
Agendia
Breast Cancer
The FLEX Registry will be implemented to operate as a large-scale, population based,
prospective registry. All patients with stage I to III breast cancer who receive
MammaPrint® and BluePrint testing on a primary breast tumor are eligible for entry into
the FLEX Registry, which is intended to enabl1 expand
The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are eligible for entry into the FLEX Registry, which is intended to enable additional study arms at low incremental effort and cost. FLEX Registry will utilize an adaptive design, where additional targeted substudies and arms can be added after the initial study is opened. Type: Observational [Patient Registry] Start Date: Apr 2017 |
An Adjunct Test Distinguishing Bacterial From Viral Etiology Improves Resource Utilization and Effi1
The University of Texas Health Science Center, Houston
Respiratory Tract Infections
The purpose of this study is to evaluate overall changes in patient management and
longer-term resource utilization between control and test arms, including (but not
limited to) additional work-up (including other diagnostic tests and consults),
antimicrobial treatments, disposition decisions and h1 expand
The purpose of this study is to evaluate overall changes in patient management and longer-term resource utilization between control and test arms, including (but not limited to) additional work-up (including other diagnostic tests and consults), antimicrobial treatments, disposition decisions and hospital length of stay (LOS) Type: Interventional Start Date: Dec 2023 |
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputat1
The University of Texas Health Science Center, Houston
Pain Management
The purpose of this study is to compare the effectiveness of innovative intervention of
breathing controlled electrical stimulation (BreEStim) and conventional electrical
stimulation (EStim) in management of neuropathic phantom limb pain in patients after limb
amputation. expand
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom limb pain in patients after limb amputation. Type: Interventional Start Date: Apr 2021 |
Histological Evaluation in the Efficacy of GentleWave in Root Canal Pulp Tissue Debridement and Dis1
The University of Texas Health Science Center, Houston
Root Canal Treatment
The purpose of this study is to understand and learn better the efficacy of GentleWave
and obtain histological evidence of the efficacy of this new technology done in-vivo expand
The purpose of this study is to understand and learn better the efficacy of GentleWave and obtain histological evidence of the efficacy of this new technology done in-vivo Type: Interventional Start Date: Jul 2024 |
Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Patients With Recurrent Posterior Fo1
The University of Texas Health Science Center, Houston
Recurrent Ependymoma
This study seeks to determine the optimum dose frequency of 5-Azacytidin (5-AZA)
infusions into the fourth ventricle of the brain. The study's primary objective is to
establish the maximum tolerated dose for infusions of 5-Azacytidine into the fourth
ventricle in patients with recurrent ependymoma.1 expand
This study seeks to determine the optimum dose frequency of 5-Azacytidin (5-AZA) infusions into the fourth ventricle of the brain. The study's primary objective is to establish the maximum tolerated dose for infusions of 5-Azacytidine into the fourth ventricle in patients with recurrent ependymoma. The study's secondary objective is to assess the antitumor activity of 5-Azacytidine infusions into the fourth ventricle based upon imaging studies and cytology. Type: Interventional Start Date: Feb 2019 |
PARTNER 3 Trial - Aortic Valve-in-Valve
Edwards Lifesciences
Aortic Stenosis
Aortic Stenosis, Severe
This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra
transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve. expand
This study will assess the safety and effectiveness of the SAPIEN 3/SAPIEN 3 Ultra transcatheter heart valve (THV) in patients with a failing aortic bioprosthetic valve. Type: Interventional Start Date: Jan 2017 |
Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children With Recurrent Posterior1
The University of Texas Health Science Center, Houston
Brain Tumor Recurrent
The goal of this clinical research study is to establish the safety of simultaneous
infusions of methotrexate and etoposide into the fourth ventricle of the brain or
resection cavity in patients with recurrent malignant posterior fossa brain tumors. These
tumors include medulloblastoma, ependymoma,1 expand
The goal of this clinical research study is to establish the safety of simultaneous infusions of methotrexate and etoposide into the fourth ventricle of the brain or resection cavity in patients with recurrent malignant posterior fossa brain tumors. These tumors include medulloblastoma, ependymoma, atypical teratoid/rhabdoid tumor or other malignant brain tumor with recurrence or progression involving anywhere in the brain and/or spine. Patients' disease must have originated in the posterior fossa of the brain. Type: Interventional Start Date: Oct 2016 |
Study to Assess the Occurrence of HPA-1a Alloimmunization in Women With Higher Risk for Fetal and N1
Rallybio IPA, LLC
Fetal and Neonatal Alloimmune Thrombocytopenia
A prospective, non-interventional, natural history study to assess the occurrence of
higher FNAIT risk across a broad population of different racial and ethnic
characteristics and the occurrence of HPA-1a alloimmunization in these women. expand
A prospective, non-interventional, natural history study to assess the occurrence of higher FNAIT risk across a broad population of different racial and ethnic characteristics and the occurrence of HPA-1a alloimmunization in these women. Type: Observational Start Date: Mar 2022 |
Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
Presage Biosciences
Solid Tumor
This is a multi-center, open-label Phase 0 Master Protocol designed to study the
localized pharmacodynamics (PD) of anti-cancer therapies within the tumor
microenvironment (TME) when administered intratumorally in microdose quantities via the
CIVO device in patients with surface accessible solid tu1 expand
This is a multi-center, open-label Phase 0 Master Protocol designed to study the localized pharmacodynamics (PD) of anti-cancer therapies within the tumor microenvironment (TME) when administered intratumorally in microdose quantities via the CIVO device in patients with surface accessible solid tumors for which there is a scheduled surgical intervention. CIVO stands for Comparative In Vivo Oncology. Multiple substudies will include specified investigational agents and combinations to be evaluated. Type: Interventional Start Date: Jul 2021 |
Developing and Testing an Implementation Strategy for Active Learning to Promote Physical Activity1
The University of Texas Health Science Center, Houston
Physical Activity
The purpose of this study is to develop an implementation strategy to improve the use and
sustainment of active learning in elementary schools and to conduct a feasibility study
to evaluate the impact of the developed implementation strategy on the implementation and
effectiveness of active learnin1 expand
The purpose of this study is to develop an implementation strategy to improve the use and sustainment of active learning in elementary schools and to conduct a feasibility study to evaluate the impact of the developed implementation strategy on the implementation and effectiveness of active learning. Type: Interventional Start Date: Aug 2023 |
Management of the PDA Trial
NICHD Neonatal Research Network
Infant, Premature
Patent Ductus Arteriosus
Infant, Newborn, Diseases
Patent Ductus Arteriosus After Premature Birth
Estimate the risks and benefits of active treatment versus expectant management of a
symptomatic patent ductus arteriosus (sPDA) in premature infants. expand
Estimate the risks and benefits of active treatment versus expectant management of a symptomatic patent ductus arteriosus (sPDA) in premature infants. Type: Interventional Start Date: Dec 2018 |
A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
Bellus Health Inc. - a GSK company
Refractory Chronic Cough
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of
BLU-5937 in participants with Refractory Chronic Cough (RCC). expand
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC). Type: Interventional Start Date: Oct 2022 |
Safe Babies: Parenting Action Plan ( PAP )
The University of Texas Health Science Center, Houston
Parenting
Motivational Interviewing
Maltreatment/Abuse
The goal is to examine the efficacy of the Parenting Action Plan (PAP), a booklet with
information that focuses on sleep hygiene, soothing a crying baby, what to do when the
baby's crying is overwhelming, identifying safe caregivers in case of emergency, and
issues surrounding feeding and bonding w1 expand
The goal is to examine the efficacy of the Parenting Action Plan (PAP), a booklet with information that focuses on sleep hygiene, soothing a crying baby, what to do when the baby's crying is overwhelming, identifying safe caregivers in case of emergency, and issues surrounding feeding and bonding with the baby. Type: Interventional Start Date: Aug 2022 |
Cognitive Behavioral Intervention to Reduce Procedural Anxiety Among Woman With High Risk Pregnanci1
University of Colorado, Denver
Procedural Anxiety
High Risk Pregnancy
Fetal Complications
The goals of this study are to determine the feasibility and efficacy of a brief,
single-session cognitive-behavioral intervention for reducing preoperative and
postoperative anxiety and for determining satisfaction with the delivery process in
pregnant women scheduled for Cesarean delivery due to1 expand
The goals of this study are to determine the feasibility and efficacy of a brief, single-session cognitive-behavioral intervention for reducing preoperative and postoperative anxiety and for determining satisfaction with the delivery process in pregnant women scheduled for Cesarean delivery due to complications with their pregnancy. This will be done through a combination of psychoeducation and exposure therapy, where the participants will be walked through the steps of a Cesarean delivery in an operating room that mimics where the patient would actually be delivering. Follow-up will occur during the immediate and extended postpartum periods to determine satisfaction and levels of anxiety. Type: Interventional Start Date: Jul 2020 |
Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms1
The University of Texas Health Science Center, Houston
Huntington Disease
The purpose of this study is to assess feasibility, acceptability, and safety of
providing transcranial direct current stimulation( tDCS) to Huntingtons Disease (HD)
patients in the early to middle stages and to assess the efficacy of tDCS for HD-related
behavioral, cognitive and other symptoms expand
The purpose of this study is to assess feasibility, acceptability, and safety of providing transcranial direct current stimulation( tDCS) to Huntingtons Disease (HD) patients in the early to middle stages and to assess the efficacy of tDCS for HD-related behavioral, cognitive and other symptoms Type: Interventional Start Date: Jun 2023 |
Breathing Rescue for SUDEP Prevention
The University of Texas Health Science Center, Houston
Focal Epilepsy
The purpose of this study is to precisely delineate human brain networks that modulate
respiration and identify specific brain areas and stimulation techniques that can be used
to prevent seizure-induced breathing failure. expand
The purpose of this study is to precisely delineate human brain networks that modulate respiration and identify specific brain areas and stimulation techniques that can be used to prevent seizure-induced breathing failure. Type: Interventional Start Date: Jul 2023 |
Perinatal Outcomes Following Change in Clinical Criteria in for Treatment of Maternal Hypertension
The University of Texas Health Science Center, Houston
Maternal Hypertension
The purpose of this study is observe outcomes before and after a change in clinical
practice in the threshold for management of severe hypertension in pregnancy and the
post-partum period. Outcomes will be observed for 10 months under the current
(traditional) clinical blood pressure threshold for1 expand
The purpose of this study is observe outcomes before and after a change in clinical practice in the threshold for management of severe hypertension in pregnancy and the post-partum period. Outcomes will be observed for 10 months under the current (traditional) clinical blood pressure threshold for acute treatment of hypertension, which is >= 160 millimeters of mercury (mmHg) systolic blood pressure (SBP). This will be followed by one month of education about rationale for the new SBP threshold of >= 180 mmHg and change of clinical guidelines. Then, there will be 10 months of observation after adopting the updated clinical threshold for acute antihypertensive treatment (>= 180 SBP). Type: Observational Start Date: May 2023 |
Trendelenburg, Abdominal Insufflation and Time to Completion of Cystoscopy
The University of Texas Health Science Center, Houston
Bladder Integrity
Bladder Function
Ureteral Integrity
Ureteral Function
Objective:
The investigators seek to compare the efficiency of the cystoscopy with two
interventions:
1. patient position during the cystoscopy (Trendelenburg (head down) or flat)
2. Abdominal insufflation (insufflation versus no insufflation) expand
Objective: The investigators seek to compare the efficiency of the cystoscopy with two interventions: 1. patient position during the cystoscopy (Trendelenburg (head down) or flat) 2. Abdominal insufflation (insufflation versus no insufflation) Type: Interventional Start Date: Apr 2023 |
Neural Connectivity During Therapy for Adolescent PTSD
The University of Texas Health Science Center at San Antonio
PTSD
Adolescent
Psychological Trauma
Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying
cognitive, social and emotional skills. Neuroimaging research that seeks to identify the
neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has
been slow using current methods1 expand
Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy. Type: Interventional Start Date: Nov 2022 |
Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT
Major Extremity Trauma Research Consortium
Post Operative Surgical Site Infection
The proposed study is a multi-center, prospective randomized controlled trial comparing
current standard of care treatment to the SEXTANT treatment protocol in patients with
Type III open fractures of the tibia and IIIB fractures of the ankle and hindfoot. expand
The proposed study is a multi-center, prospective randomized controlled trial comparing current standard of care treatment to the SEXTANT treatment protocol in patients with Type III open fractures of the tibia and IIIB fractures of the ankle and hindfoot. Type: Interventional Start Date: May 2021 |
UTHealth Turner Syndrome Research Registry
The University of Texas Health Science Center, Houston
Turner Syndrome
The investigators will conduct genetic comparisons between Turner Syndrome (TS) patients
with and without Bicuspid Aortic Valve (BAV) to identify causative agents of BAV in
people with TS.
The investigators will correlate the patterns and prevalence of structural heart defects
in TS women with eme1 expand
The investigators will conduct genetic comparisons between Turner Syndrome (TS) patients with and without Bicuspid Aortic Valve (BAV) to identify causative agents of BAV in people with TS. The investigators will correlate the patterns and prevalence of structural heart defects in TS women with emerging molecular data to identify patients who are at high risk for cardiovascular complications Type: Observational [Patient Registry] Start Date: Aug 2015 |
Financial Coaching and Lifestyle Intervention for Diabetes Prevention in Low-income Families
The University of Texas Health Science Center, Houston
Weight Loss
The purpose of this study is to compare the effect on weight and metabolic outcomes of an
enhanced intervention, comprised of evidence-based financial coaching plus a lifestyle
intervention vs. the lifestyle intervention alone expand
The purpose of this study is to compare the effect on weight and metabolic outcomes of an enhanced intervention, comprised of evidence-based financial coaching plus a lifestyle intervention vs. the lifestyle intervention alone Type: Interventional Start Date: May 2023 |
A Telerehabilitation Program for SCI
The University of Texas Health Science Center, Houston
Incomplete Spinal Cord Injury
This study evaluates a remotely supervised, home-based therapeutic program to improve
upper-limb voluntary movement in adults with tetraplegia caused by incomplete spinal cord
injury (iSCI). expand
This study evaluates a remotely supervised, home-based therapeutic program to improve upper-limb voluntary movement in adults with tetraplegia caused by incomplete spinal cord injury (iSCI). Type: Interventional Start Date: Jul 2021 |
Evaluation of Hemostasis in Bleeding and Thrombotic Disorders
The University of Texas Health Science Center, Houston
Blood Coagulation Disorders, Inherited
Thrombotic Disorder
The objective of this study will be to assess the coagulation system in-vitro in a
variety of bleeding and clotting disorders using the ROTEG analyzer and the thrombin
generation assay. expand
The objective of this study will be to assess the coagulation system in-vitro in a variety of bleeding and clotting disorders using the ROTEG analyzer and the thrombin generation assay. Type: Observational Start Date: Oct 2002 |
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