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Purpose

The purpose of this study is observe outcomes before and after a change in clinical practice in the threshold for management of severe hypertension in pregnancy and the post-partum period. Outcomes will be observed for 10 months under the current (traditional) clinical blood pressure threshold for acute treatment of hypertension, which is >= 160 millimeters of mercury (mmHg) systolic blood pressure (SBP). This will be followed by one month of education about rationale for the new SBP threshold of >= 180 mmHg and change of clinical guidelines. Then, there will be 10 months of observation after adopting the updated clinical threshold for acute antihypertensive treatment (>= 180 SBP).

Condition

Eligibility

Eligible Ages
All ages
Eligible Genders
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • any individual > 20 weeks' gestation in triage or admitted at Children's Memorial Hermann Hospital (CMHH) and with blood pressure with >= 160/110 mmHg

Exclusion Criteria

  • Active seizure, stroke, Congestive Heart Failure (CHF)/pulmonary edema, acute kidney injury (AKI), or myocardial infarction (MI) - A history of stroke, CHF, chronic kidney disease (CKD), MI - Have Hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome or thrombocytopenia (platelets < 100×10^9/L) - Persistent neurologic symptoms including headache >8/10 one hour after analgesic or blurry vision/loss of vision

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Traditional clinical blood pressure threshold of SBP >= 160 mmHg for acute treatment of hypertension
  • Procedure: Clinical blood pressure threshold of SBP >= 160 mmHg for acute treatment of hypertension
    Patients are treated for hypertension if SBP >= 160 mmHg.
Updated clinical blood pressure threshold of SBP >= 180 mmHg for acute treatment of hypertension
  • Procedure: Clinical blood pressure threshold of SBP >= 180 mmHg for acute treatment of hypertension
    Patients are treated for hypertension if SBP >= 180 mmHg.

Recruiting Locations

UT Houston
Houston, Texas 77004
Contact:
Kristen A Cagino, MD
518-859-8312
kristen.a.cagino@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center, Houston

Study Contact

Kristen Cagino, MD
713-500-6412
Kristen.A.Cagino@uth.tmc.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.