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Purpose

The purpose of this study is to assess the feasibility, acceptability, and efficacy of self-administered transcranial direct current stimulation (tDCS) in older adults with knee osteoarthritis (OA)

Condition

Eligibility

Eligible Ages
Between 50 Years and 85 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • have symptomatic knee OA based on American College of Rheumatology Clinical criteria - have had knee OA pain in the past 3 months with an average of at least 30 on a 0-100 NRS for pain - can speak and read English - have no plan to change medication regimens for pain throughout the trial

Exclusion Criteria

  • prosthetic knee replacement or nonarthroscopic surgery to the affected knee - history of brain surgery, brain tumor, seizure, stroke or intracranial metal implantation - systemic rheumatic disorders, including rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia - alcohol/substance abuse - current use of sodium channel blockers, calcium channel blockers and NMDS receptor antagonists - diminished cognitive function that would interfere with understanding study procedures(i.e., Mini-Mental Status Exam score ≤ 23) - pregnancy or lactation - hospitalization within the preceding year for psychiatric illness - no access to a device with internet access that can be used for secure videoconferencing for real-time remote supervision

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Active tDCS
  • Device: Active tDCS
    tDCS with a constant current intensity of 2 mA will be applied for 20 minutes per session daily for 2 weeks (Monday to Friday) via the Soterix 1x1 tDCS mini-CT Stimulator device (Soterix Medical Inc., NY) with headgear and saline-soaked surface sponge electrodes.
    Other names:
    • Soterix 1x1 tDCS mini-CT Stimulator
Placebo Comparator
Sham tDCS
  • Device: Sham tDCS
    For sham stimulation, the electrodes will be placed in the same positions as for active stimulation, but the stimulator will only deliver 2 mA current for 30 seconds.
    Other names:
    • Soterix 1x1 tDCS mini-CT Stimulator

More Details

Status
Completed
Sponsor
Florida State University

Study Contact

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.