Self-Administered Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis

Purpose

The purpose of this study is to assess the feasibility, acceptability, and efficacy of self-administered transcranial direct current stimulation (tDCS) in older adults with knee osteoarthritis (OA)

Condition

  • Osteo Arthritis Knee

Eligibility

Eligible Ages
Between 50 Years and 85 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • have symptomatic knee OA based on American College of Rheumatology Clinical criteria - have had knee OA pain in the past 3 months with an average of at least 30 on a 0-100 NRS for pain - can speak and read English - have no plan to change medication regimens for pain throughout the trial

Exclusion Criteria

  • prosthetic knee replacement or nonarthroscopic surgery to the affected knee - history of brain surgery, brain tumor, seizure, stroke or intracranial metal implantation - systemic rheumatic disorders, including rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia - alcohol/substance abuse - current use of sodium channel blockers, calcium channel blockers and NMDS receptor antagonists - diminished cognitive function that would interfere with understanding study procedures(i.e., Mini-Mental Status Exam score ≤ 23) - pregnancy or lactation - hospitalization within the preceding year for psychiatric illness - no access to a device with internet access that can be used for secure videoconferencing for real-time remote supervision

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Active tDCS
  • Device: Active tDCS
    tDCS with a constant current intensity of 2 mA will be applied for 20 minutes per session daily for 2 weeks (Monday to Friday) via the Soterix 1x1 tDCS mini-CT Stimulator device (Soterix Medical Inc., NY) with headgear and saline-soaked surface sponge electrodes.
    Other names:
    • Soterix 1x1 tDCS mini-CT Stimulator
Placebo Comparator
Sham tDCS
  • Device: Sham tDCS
    For sham stimulation, the electrodes will be placed in the same positions as for active stimulation, but the stimulator will only deliver 2 mA current for 30 seconds.
    Other names:
    • Soterix 1x1 tDCS mini-CT Stimulator

More Details

Status
Completed
Sponsor
Florida State University

Study Contact