Purpose

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Adults with severe sepsis or septic shock on mechanical ventilation - Enrolled in the initial six hours of ICU admission

Exclusion Criteria

  • Patients with withdrawal or hospice order. - Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission. - Patients with COPD. - Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Multi-organ failure Alveolar dead space on mechanically ventilated patients with severe sepsis or septic shock.

Recruiting Locations

Memorial Hermann Hospital
Houston, Texas 77030
Contact:
Rosa M Estrada-Y-Martin, MD MSc
713-500-6830
rosa.m.estrada.y.martin@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center, Houston

Study Contact

Rosa M Estrada-Y-Martin, MD MSc
713-500-6830
rosa.m.estrada.y.martin@uth.tmc.edu

Detailed Description

The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation. Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.