Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis
Purpose
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.
Conditions
- Sepsis
- Severe Sepsis
- Septic Shock
- Multi-organ Failure
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Adults with severe sepsis or septic shock on mechanical ventilation - Enrolled in the initial six hours of ICU admission
Exclusion Criteria
- Patients with withdrawal or hospice order. - Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission. - Patients with COPD. - Patients transferred from outside ICU with ongoing sepsis management for more than six hours.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Multi-organ failure | Alveolar dead space on mechanically ventilated patients with severe sepsis or septic shock. |
Recruiting Locations
Memorial Hermann Hospital
Houston, Texas 77030
Houston, Texas 77030
More Details
- Status
- Recruiting
- Sponsor
- The University of Texas Health Science Center, Houston
Detailed Description
The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation. Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.