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TRIAD Appendicitis Decision-making Surveys
University of Washington
Appendicitis
While appendectomy has been the main treatment of appendicitis for over 100 years, recent
European studies found that, at least among highly selected patients, antibiotics alone can
be an effective alternative. Surgeons and patients alike have a difficult time deciding if... expand
While appendectomy has been the main treatment of appendicitis for over 100 years, recent European studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative. Surgeons and patients alike have a difficult time deciding if surgery or antibiotics are the best choice to treat appendicitis. The goal of the TRIAD is to evaluate the patients who are a part of the TRIAD implementation program and assess satisfaction and decisional regret for patients with appendicitis. This information will be used to inform the design of decision-support interventions to help patients improve their ability to make an informed decision in-line with their preferences and values. Type: Observational Start Date: Oct 2022 |
Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset
The University of Texas Health Science Center, Houston
Infant, Extremely Premature
Obstetric Labor, Premature
Premature Birth
Intensive Care, Neonatal
Intensive Care Units, Neonatal
The goal of the Tiny Baby Collaborative Multicenter Inventory of Neonatal-Perinatal
Interventions (MINI) minimum dataset is to serve as a registry detailing the outcomes and
practices for all deliveries and infants admitted to intensive care at 22-23 weeks' gestation
at participating... expand
The goal of the Tiny Baby Collaborative Multicenter Inventory of Neonatal-Perinatal Interventions (MINI) minimum dataset is to serve as a registry detailing the outcomes and practices for all deliveries and infants admitted to intensive care at 22-23 weeks' gestation at participating hospitals. Type: Observational [Patient Registry] Start Date: Jan 2019 |
A Prospective and Retrospective Observational Study of Multidrug-Resistant Patient Outcomes With and...
Theratechnologies
HIV Infections
Multi-Antiviral Resistance
The virological efficacy of ibalizumab has been clearly demonstrated in multiple clinical
trials. This study will expand ibalizumab's clinical data set and allow a better
understanding of the virologic response durability on ARV regimens with or without ibalizumab
in a heterogeneous... expand
The virological efficacy of ibalizumab has been clearly demonstrated in multiple clinical trials. This study will expand ibalizumab's clinical data set and allow a better understanding of the virologic response durability on ARV regimens with or without ibalizumab in a heterogeneous real-world patient population. Additional data on the efficacy and safety of ibalizumab and its impact on patient reported outcomes will be captured until study end. Primary Objective: To evaluate the long-term efficacy, safety, and durability of ibalizumab in combination with other ARVs by comparing the virologic, immunologic and clinical outcomes of patients receiving ibalizumab treatment versus patients not receiving ibalizumab. Secondary Objective: To assess the efficacy of ibalizumab in combination with other antiretrovirals by comparing the virologic, immunologic, clinical and patient reported outcomes of patients before and after they receive ibalizumab treatment. To assess the long-term safety and tolerability of ibalizumab. Other Objectives: To assess risk factors/predictors of virologic and immunologic response. To assess efficacy and safety in special populations that enroll. Type: Observational Start Date: Mar 2022 |
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
The University of Texas Health Science Center, Houston
PreDiabetes
This project uses both transcriptomic- and genomic-level data to identify mechanisms of
individual responses to glucagon-like peptide-1 (GLP-1) in Mexican-Americans with
prediabetes. The GLP-1 hormone is essential for glucose reduction, weight loss,
cardiovascular risk reduction,... expand
This project uses both transcriptomic- and genomic-level data to identify mechanisms of individual responses to glucagon-like peptide-1 (GLP-1) in Mexican-Americans with prediabetes. The GLP-1 hormone is essential for glucose reduction, weight loss, cardiovascular risk reduction, and renal protection. Newly discovered mechanisms will illuminate causal links between disease genotype and phenotype, which may ultimately guide personalized therapeutic approaches for type 2 diabetes, prediabetes, obesity, cardiovascular disease, renal disease, and other related diseases. Type: Interventional Start Date: Nov 2021 |
Study of Individuals Affected With Hypoplasminogenemia
Indiana Hemophilia &Thrombosis Center, Inc.
Plasminogen Deficiency
This is an Investigator initiated retrospective and prospective single cohort study. The
study will utilize an international registry and develop a specimen biobank to provide an
improved understanding of the natural history of hyposplasminogenemia, to elucidate the
heterogeneity... expand
This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved therapeutic modalities Type: Observational Start Date: Dec 2018 |
DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma
ECOG-ACRIN Cancer Research Group
Gliosarcoma
Recurrent Glioblastoma
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic
resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for
early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may
help... expand
This phase II trial studies how well dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) works in measuring relative cerebral blood volume (rCBV) for early response to bevacizumab in patients with glioblastoma that has come back. DSC-MRI may help evaluate changes in the blood vessels within the cancer to determine a patient?s response to treatment. Type: Interventional Start Date: Jul 2017 |
Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory...
The University of Texas Health Science Center, Houston
Chronic Rhinitis
The purpose of this study is to assess the effectiveness of radiofrequency ablation (RFA) of
the posterior nasal nerve (PNN) in chronic rhinitis (CR) patients by comparing patient
reflective total nasal symptom score (rTNSS) and nasal obstruction symptom evaluation (NOSE)... expand
The purpose of this study is to assess the effectiveness of radiofrequency ablation (RFA) of the posterior nasal nerve (PNN) in chronic rhinitis (CR) patients by comparing patient reflective total nasal symptom score (rTNSS) and nasal obstruction symptom evaluation (NOSE) , peak nasal inspiratory flow (PNIF) , and levels of Type 2 cytokines pre- and post-procedure. Type: Interventional Start Date: Jan 2023 |
Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention
The University of Texas Health Science Center, Houston
Cocaine Use Disorder
The purpose of this study is to see how well pioglitazone, when used with cognitive
behavioral therapy, works at helping people who have recently stopped using cocaine to
continue to not use cocaine.
expand
The purpose of this study is to see how well pioglitazone, when used with cognitive behavioral therapy, works at helping people who have recently stopped using cocaine to continue to not use cocaine. Type: Interventional Start Date: Aug 2021 |
A Comparative Study of Hall Technique, Modified Hall Technique and Conventional Stainless-Steel Crown...
The University of Texas Health Science Center, Houston
Dental Caries
The purpose of this study is to compare the effectiveness of the Hall technique and modified
Hall technique to the conventional Stainless-Steel Crown restoration in the treatment of
primary molars with dentinal caries with or without proximal ridge intact.
expand
The purpose of this study is to compare the effectiveness of the Hall technique and modified Hall technique to the conventional Stainless-Steel Crown restoration in the treatment of primary molars with dentinal caries with or without proximal ridge intact. Type: Interventional Start Date: Jun 2023 |
Building Resilience In Caregivers of Trauma Survivors
The University of Texas Health Science Center, Houston
Caregiver Burnout
The purpose of the study is to examine the role of demographics, pre-existing anxiety,
depression, and substance use on caregiver depression anxiety, and substance use following a
critical injury to a loved one,evaluate the factors that mediate the effectiveness of
traditional,... expand
The purpose of the study is to examine the role of demographics, pre-existing anxiety, depression, and substance use on caregiver depression anxiety, and substance use following a critical injury to a loved one,evaluate the factors that mediate the effectiveness of traditional, psychotherapy using problem solving therapy to reduce depression, anxiety, and substance use and to evaluate the factors that mediate the effectiveness of providing an ICU diary and instruction on that diary to reduce depression, anxiety, and substance use. Type: Interventional Start Date: Mar 2022 |
A Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (ActiveMatrix) Verses...
The University of Texas Health Science Center, Houston
Adhesive Capsulitis
The purpose of this study is to compare ActiveMatrix® to standard of care corticosteroid
injection in the treatment of adhesive capsulitis of the shoulder (frozen shoulder).
expand
The purpose of this study is to compare ActiveMatrix® to standard of care corticosteroid injection in the treatment of adhesive capsulitis of the shoulder (frozen shoulder). Type: Interventional Start Date: Jan 2023 |
BIOlogic Augmented Repair of Complex Anal Fistula Using Acellular Matrix and/or Autologous Platelet-rich...
The University of Texas Health Science Center, Houston
Anal Fistula
The purpose of this study is to compare the clinical effectiveness of augmenting surgical
repair of complex anal fistula using autologous PRP and/or micronized acellular porcine
urinary bladder matrix (UBM) to usual surgical care alone to prevent fistula recurrence or
improve... expand
The purpose of this study is to compare the clinical effectiveness of augmenting surgical repair of complex anal fistula using autologous PRP and/or micronized acellular porcine urinary bladder matrix (UBM) to usual surgical care alone to prevent fistula recurrence or improve HRQoL, to compare the effects of augmenting surgical repair of complex anal fistula using autologous PRP and/or micronized acellular porcine urinary bladder matrix on early postoperative pain and fecal continence and to assess the cost utility of augmented complex fistula repair relative to usual surgical care Type: Interventional Start Date: Feb 2023 |
Feasibility of Mindfulness Meditation Training and Home Practice in Persons With Spinal Cord Injury
The University of Texas Health Science Center, Houston
Spinal Cord Injuries
The purpose of this study is to evaluate the feasibility and acceptability of a 6-week
app-guided Mindfulness meditation training (MM) intervention and health education (active
control) condition in people with spinal cord injury (SCI) who have chronic pain and to
examine... expand
The purpose of this study is to evaluate the feasibility and acceptability of a 6-week app-guided Mindfulness meditation training (MM) intervention and health education (active control) condition in people with spinal cord injury (SCI) who have chronic pain and to examine the feasibility of data collection procedures Type: Interventional Start Date: Dec 2022 |
Study in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of...
Peptilogics
Joint Infection
The purpose of this study is to learn about the safety and effects of PLG0206 for treating
periprosthetic joint infections (PJI) in conjunction with the DAIR (debridement, antibiotics
and implant retention) surgical procedure for patients with periprosthetic joint infections... expand
The purpose of this study is to learn about the safety and effects of PLG0206 for treating periprosthetic joint infections (PJI) in conjunction with the DAIR (debridement, antibiotics and implant retention) surgical procedure for patients with periprosthetic joint infections (PJI) after total knee arthroplasty (TKA) . Type: Interventional Start Date: Mar 2022 |
Brighter Bites & UT Physicians Produce Rx Program
The University of Texas Health Science Center, Houston
Obesity, Childhood
The purpose of this study is to clinically evaluate the effectiveness of an at-home produce
delivery prescription or grocery store vouchers prescription at improving weight status and
obesity-related health outcomes of participants across the two clinics as compared to a
control... expand
The purpose of this study is to clinically evaluate the effectiveness of an at-home produce delivery prescription or grocery store vouchers prescription at improving weight status and obesity-related health outcomes of participants across the two clinics as compared to a control group and to examine the impacts of the program on child dietary behavioral outcomes (child fruit and vegetable intake, junk food consumption, and eating at any type of restaurant), and parent feeding practices (preparing foods from scratch, use of nutrition facts labels to make purchasing decisions, and eating meals with their referent child) Type: Interventional Start Date: Oct 2022 |
Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical...
The University of Texas Health Science Center, Houston
Periodontal Diseases
The purpose of this study is to compare clinical outcomes after mechanical debridement of at
sites exhibiting plaque induced inflammation with or without adjunctive Antimicrobial
photodynamic therapy (aPDT) and to assess the the microbiologic profile before and after
treatment... expand
The purpose of this study is to compare clinical outcomes after mechanical debridement of at sites exhibiting plaque induced inflammation with or without adjunctive Antimicrobial photodynamic therapy (aPDT) and to assess the the microbiologic profile before and after treatment with or without aPDT Type: Interventional Start Date: Apr 2022 |
Integration of PE & Coping Long-Term With Active Suicide Program for PTSD & Suicide Risk in Military...
The University of Texas Health Science Center, Houston
Post Traumatic Stress Disorder
Suicidal Ideation
The purpose of this study is to develop an innovative, safe, acceptable, feasible, and
efficacious integrated CLASP-PE intervention and to Collect pilot data to evaluate the
preliminary evidence of the promise of the intervention. We hypothesize that the CLASP-PE
intervention... expand
The purpose of this study is to develop an innovative, safe, acceptable, feasible, and efficacious integrated CLASP-PE intervention and to Collect pilot data to evaluate the preliminary evidence of the promise of the intervention. We hypothesize that the CLASP-PE intervention will demonstrate safety, acceptability, feasibility, and efficacy in the open trial. Type: Interventional Start Date: Oct 2021 |
Prenatal Genetic Diagnosis by Genomic Sequencing
Columbia University
Fetal Structural Anomalies
This study is evaluating the impact of prenatal sequencing on the management of fetuses with
ultrasound abnormalities. The hypothesis is that a significant subset of fetal abnormalities
have a genetic cause that can be identified by sequencing and that prenatal knowledge of this... expand
This study is evaluating the impact of prenatal sequencing on the management of fetuses with ultrasound abnormalities. The hypothesis is that a significant subset of fetal abnormalities have a genetic cause that can be identified by sequencing and that prenatal knowledge of this information will improve prenatal care, reduce unnecessary diagnostic testing, reduce the cost of care, and improve the quality of life for both the child and the family. Type: Observational Start Date: Jun 2019 |
Serum Bovine Immunoglobulin (SBI) in Children and Young Adults With Inflammatory Bowel Disease (IBD)
Monisha Hitesh Shah
Inflammatory Bowel Diseases
Ulcerative Colitis
Crohn Disease
This is a randomized, double-blind placebo controlled study to assess for safety,
tolerability and nutritional impact of oral serum bovine immunoglobulin (SBI) on pediatric
patients and young adults with inflammatory bowel disease (IBD) as assessed by an increase in
serum... expand
This is a randomized, double-blind placebo controlled study to assess for safety, tolerability and nutritional impact of oral serum bovine immunoglobulin (SBI) on pediatric patients and young adults with inflammatory bowel disease (IBD) as assessed by an increase in serum albumin and other nutritional markers including vitamin D level, pre-albumin, transferrin and iron saturation; and improvement in weight and body mass index. SBI is an animal derived protein isolate from the serum of cows containing >50% IgG. It has been used for patients suffering from irritable bowel syndrome, human immunodeficiency virus enteropathy and antibiotic-associated diarrhea for symptomatic relief of diarrhea with good results and minimal side effects. However its role in IBD has not yet been investigated. The investigators hypothesize that the study product will have a positive nutritional impact along with symptom improvement for pediatric and young adult patients with IBD. The volunteers for our study will have established Crohn's disease or ulcerative colitis and will be treated with a daily powder (SBI or placebo) added to their breakfast food (egg, yogurt, or peanut butter are best) for total of 60 days followed by 30 day monitoring period after completion of treatment. The volunteers will be followed by clinic visits and labs on day 0, day 15, day 60 and day 90. There is the potential for the treatment to alter disease activity, a secondary outcome, as assessed by measurement of serum markers of inflammation (ESR, CRP), fecal calprotectin (validated marker of intestinal inflammation), and clinical indices like short pediatric Crohn's disease activity index (shPDCAI) or pediatric ulcerative colitis activity index (PUCAI) for children and Harvey Bradshaw Index or SCCAI for adults. Stool samples will be collected on day 0 and day 60 for 16S RNA sequencing to assess for changes in microbiota of the participants while on the study product/placebo. We plan to enroll 43 patients in the study to allow for data analysis of atleast 30 patients. The study will take place over 1 year and will be conducted at University of Texas-Children's Memorial Hermann Hospital, where we follow > 125 children with inflammatory bowel disease. Type: Interventional Start Date: Sep 2020 |
Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
The University of Texas Health Science Center, Houston
Intractable Epilepsy
To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative
workup of children with intractable epilepsy referred for surgery.
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To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery. Type: Interventional Start Date: Nov 2015 |
Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
The University of Texas Health Science Center, Houston
Spastic Diplegia
The purpose of this study is to characterize the cortical connectivity changes in the brain
of spastic diplegic children after Selective Dorsal Rhizotomy.
expand
The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy. Type: Interventional Start Date: Aug 2015 |
Reclaim™ Deep Brain Stimulation (DBS) Therapy for Obsessive-Compulsive Disorder (OCD)
The University of Texas Health Science Center, Houston
Obsessive-Compulsive Disorder (OCD)
There are two primary approaches to the treatment of OCD, pharmacotherapy and cognitive
behavior therapy (CBT). Lack of therapeutic success with one approach leads to trials of the
alternative approach or a combination of the two. A rarely used third therapy approach,
appropriate... expand
There are two primary approaches to the treatment of OCD, pharmacotherapy and cognitive behavior therapy (CBT). Lack of therapeutic success with one approach leads to trials of the alternative approach or a combination of the two. A rarely used third therapy approach, appropriate for only the most severely afflicted and treatment resistant patients, is neurosurgical ablation of certain brain regions involved in mood and anxiety. The neurosurgical ablation procedures are irreversible in nature, and involve the destruction of specific volumes of brain tissue through various controlled means. Surgical procedures include cingulotomy, subcaudate tractotomy, limbic leucotomy which is a combination of the first two procedures and capsulotomy. DBS therapy is an alternative to neurosurgical procedures, specifically anterior capsulotomy, for patients with chronic, severe OCD which has proven resistant to primary pharmacological and/or behavior therapy options. Results from 26 severe, treatment-resistant OCD patients treated with DBS at four collaborating centers, three in the US, and one in Europe are summarized in great detail in pages 12-22 of the provided/attached "Reclaim Summary of Safety and Probable Benefit." Type: Interventional Start Date: Aug 2021 |
DynaCleft® Effects on Soft Tissues and on Quality of Life for Incomplete Unilateral Cleft Lip Infants
The University of Texas Health Science Center, Houston
Cleft Lip and Palate
The purpose of this study is to examine the effectiveness of the DynaCleft® system on soft
tissues of infants with unilateral incomplete cleft lip and to assess influences on quality
of life for infants who underwent DynaCleft® and that of their families.
expand
The purpose of this study is to examine the effectiveness of the DynaCleft® system on soft tissues of infants with unilateral incomplete cleft lip and to assess influences on quality of life for infants who underwent DynaCleft® and that of their families. Type: Interventional Start Date: Sep 2020 |
Spinal Cord Injury Registry - North American Clinical Trials Network
Robert G. Grossman, MD
Spinal Cord Injury
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting
de-identified data from patients admitted through the Emergency Department of a NACTN center
at the time of injury with an initial (first time) spinal cord injury (SCI). Information will
be collected... expand
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI). Information will be collected on the natural history of SCI and course of treatment through the first 12 months from the date of injury or long as medically indicated. Data collected includes imaging information from CT or MRI scans, neurological and general medical outcome and rehabilitation evaluation. No intervention is given other than standard of care for spinal cord injury, intensive monitoring and frequent follow up care. Type: Observational Start Date: Jul 2005 |
VENOUS: A Translational Study of Enterococcal Bacteremia
The University of Texas Health Science Center, Houston
Enterococcal Bacteremia
The purpose of this study is to assemble a multicenter prospective cohort of patients with
enterococcal bloodstream infections (BSIs) to provide data on outcomes of patients with
enterococcal BSIs for sample size calculations for future trials, as well as to characterize
enterococcal... expand
The purpose of this study is to assemble a multicenter prospective cohort of patients with enterococcal bloodstream infections (BSIs) to provide data on outcomes of patients with enterococcal BSIs for sample size calculations for future trials, as well as to characterize enterococcal isolates causing BSIs in order to comprehensively dissect the molecular epidemiology of infecting organisms for future studies. Type: Observational [Patient Registry] Start Date: Aug 2016 |
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