Search Clinical Trials
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Helix Research Network
Helix, Inc
Genetic Predisposition to Disease
Genetics Disease
The Helix Research Network ("HRN") is a network of academic, public, and/or private
healthcare organizations that are committed to advancing medical research and improving
human health through large-scale genomics research and acceleration of the integration of
genomic and other omics data into clinical... expand
The Helix Research Network ("HRN") is a network of academic, public, and/or private healthcare organizations that are committed to advancing medical research and improving human health through large-scale genomics research and acceleration of the integration of genomic and other omics data into clinical care. Type: Observational Start Date: Sep 2021 |
Autologous Adipose Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
Hope Biosciences
Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the
potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences
adipose-derived mesenchymal stem cells) on brain structure, neurocognitive/functional
outcomes, and neuroinflammation after traumatic... expand
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure, neurocognitive/functional outcomes, and neuroinflammation after traumatic brain injury and/or hypoxic-ischemic encephalopathy in adults. Type: Interventional Start Date: Apr 2024 |
Study to Evaluate the Fecal Microbiota Transplantation (FMT) in the Treatment of Ulcerative Colitis
The University of Texas Health Science Center, Houston
Active Ulcerative Colitis (UC)
The study is to evaluate the safety, feasibility, and preliminary efficacy of frozen FMT
delivery via retention enema compared to lyophilized powder given in oral capsules as
induction FMT in subjects with active UC. This study will also determine changes in
microbiome (diversity and genera) and proportion... expand
The study is to evaluate the safety, feasibility, and preliminary efficacy of frozen FMT delivery via retention enema compared to lyophilized powder given in oral capsules as induction FMT in subjects with active UC. This study will also determine changes in microbiome (diversity and genera) and proportion of antibody-coated microbiota from baseline to after completion of FMT. Type: Interventional Start Date: Dec 2023 |
Meal Delivery and Exercise
The University of Texas Health Science Center, Houston
Frailty
The purpose of this study is to evaluate the effects of a home-based exercise program
administered through Meals on wheels (MOW) on gait speed and frailty status and to assess
the association between novel serum biomarkers (70 kilodalton heat shock proteins
(HSP70),Macrophage Inflammatory Proteins(MIP1b),... expand
The purpose of this study is to evaluate the effects of a home-based exercise program administered through Meals on wheels (MOW) on gait speed and frailty status and to assess the association between novel serum biomarkers (70 kilodalton heat shock proteins (HSP70),Macrophage Inflammatory Proteins(MIP1b), soluble IL-6 receptor alpha-chain (sIL-6R)) and established but non-specific frailty biomarkers (Interleukin 6 (IL-6), C-reactive protein (CRP), Tumor necrosis factor (TNF-α)) in frail and prefrail homebound older adults before and after the exercise intervention. Type: Interventional Start Date: Jul 2021 |
Evaluation of Aerosol in a Dental Clinic
The University of Texas Health Science Center, Houston
Covid19
The purpose of this study is to evaluate the effectiveness of external evacuation units
and mouth rinses during aerosol generating procedures in a dental clinic and to determine
the risk level to the dental practitioners during aerosol generating procedures. expand
The purpose of this study is to evaluate the effectiveness of external evacuation units and mouth rinses during aerosol generating procedures in a dental clinic and to determine the risk level to the dental practitioners during aerosol generating procedures. Type: Interventional Start Date: Jul 2021 |
Yield of Diagnostic Tests and Effects of Crofelemer for Chronic Idiopathic Diarrhea In Non-HIV Patients
The University of Texas Health Science Center, Houston
Chronic Diarrhea of Unknown Origin
The purpose of this study is to evaluate the effectiveness of the drug Crofelemer in the
treatment of non-HIV patients with chronic idiopathic diarrhea; to determine the
prevalence of identifiable causes of chronic diarrhea in a non-HIV patients; to assess
the diagnostic yield, in terms of identification... expand
The purpose of this study is to evaluate the effectiveness of the drug Crofelemer in the treatment of non-HIV patients with chronic idiopathic diarrhea; to determine the prevalence of identifiable causes of chronic diarrhea in a non-HIV patients; to assess the diagnostic yield, in terms of identification of treatable etiologies, of commercially available diagnostic evaluations in adult, non-HIV patients with chronic idiopathic diarrhea, that is, evaluate which tests, among the standard diagnostic tests commonly conducted as part of the evaluation of chronic idiopathic diarrhea, are most likely to identify a treatable cause of the diarrhea; and to analyze the relationship between chronic idiopathic diarrhea and health-related quality of life and assess the impact of crofelemer treatment on health-related quality of life. Type: Interventional Start Date: Apr 2019 |
Combination Probiotic: BB-12 With LGG (Different Doses) in Treating Children With Autism Spectrum Disorder
The University of Texas Health Science Center, Houston
Autism Spectrum Disorder
Gastrointestinal Symptoms
This protocol is a blinded randomized controlled study of the effects of BB-12 with LGG
at different doses in 70 healthy children with autism spectrum disorders at lower and
higher doses over an 56-day period and a 28- day observation period. The study is being
conducted in order to assess safety... expand
This protocol is a blinded randomized controlled study of the effects of BB-12 with LGG at different doses in 70 healthy children with autism spectrum disorders at lower and higher doses over an 56-day period and a 28- day observation period. The study is being conducted in order to assess safety and tolerability of the probiotic (BB-12 with LGG) at 2 different doses of BB-12 with LGG. Identifying effects on behaviors in healthy children with ASD using SRS-2 and ABC, GI symptoms using GI symptom severity index, and relevant biomarkers of inflammation, microbiota, and metabolites. Primary testing and procedures will be conducted at the University of Texas Health Science Center at Houston and Memorial Hermann. Biomarker identification includes Integrative analysis of plasma metabolome and stool microbiota will be conducted with the collaboration of Dr. Ruth Ann Luna and Dr. Jim Versalovic at Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology & Microbiology of Baylor College of Medicine. Type: Interventional Start Date: May 2016 |
Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction...
The University of Texas Health Science Center, Houston
Smooth Muscle Dysfunction Syndrome (SMDS)
The purpose of this study is to determine whether SMDS patients treated with NR at the
proposed dose exhibit decreased glucose uptake in the aorta, to determine if NR treatment
results in measurable changes of blood NAD+ and NR levels, to determine if aortic
measurements are stable after treatment... expand
The purpose of this study is to determine whether SMDS patients treated with NR at the proposed dose exhibit decreased glucose uptake in the aorta, to determine if NR treatment results in measurable changes of blood NAD+ and NR levels, to determine if aortic measurements are stable after treatment with NR and to evaluate the safety and tolerability of NR in SMDS patients. Type: Interventional Start Date: Mar 2024 |
Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy
The University of Texas Health Science Center, Houston
Chemotherapy-induced Neuropathy
The proposed randomized control trial will evaluate auricular point acupressure (APA) on
chemotherapy-induced neuropathy (CIN), rigorously considering point specificity and
placebo effects by integrating self-report measures, psychophysical measures (QST),
endogenous biomarkers (cytokines), and neuro-imaging... expand
The proposed randomized control trial will evaluate auricular point acupressure (APA) on chemotherapy-induced neuropathy (CIN), rigorously considering point specificity and placebo effects by integrating self-report measures, psychophysical measures (QST), endogenous biomarkers (cytokines), and neuro-imaging to investigate APA's efficacy and underlying mechanism(s). Type: Interventional Start Date: Jul 2021 |
Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
Impulse Dynamics
Heart Failure
The OPTIMIZER Smart Post-Approval Study is a prospective, multi-center, non-randomized,
single arm open label study of 620 subjects receiving an OPTIMIZER implant as standard of
care. Patients to be included will have NYHA functional class III symptoms and a left
ventricular ejection fraction of 25-45% expand
The OPTIMIZER Smart Post-Approval Study is a prospective, multi-center, non-randomized, single arm open label study of 620 subjects receiving an OPTIMIZER implant as standard of care. Patients to be included will have NYHA functional class III symptoms and a left ventricular ejection fraction of 25-45% Type: Observational [Patient Registry] Start Date: Jan 2020 |
Non-invasive Trigeminal and Vagus Nerve Stimulation for Stroke Subjects With Chronic Upper Extremity...
NeuraStasis, Inc
Stroke, Ischemic
Upper Extremity Paresis
This is a single-center, pilot study of up to 25 subjects with residual upper extremity
deficits at least six months after an ischemic stroke. The purpose of the study is to
evaluate the initial clinical safety, device functionality, and treatment effect of
non-invasive electrical stimulation of the... expand
This is a single-center, pilot study of up to 25 subjects with residual upper extremity deficits at least six months after an ischemic stroke. The purpose of the study is to evaluate the initial clinical safety, device functionality, and treatment effect of non-invasive electrical stimulation of the trigeminal and/or vagus nerves (nTVNS) using the NeuraStasis Stimulator System adjunctive to rehabilitation. Subjects will either receive the intervention or control-sham stimulation. The study will inform the design and implementation of a pivotal study. Type: Interventional Start Date: Mar 2024 |
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After...
Northwell Health
Essential Tremor
The purpose of this study is to elucidate the structural connectivity of the
dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt
stimulation expand
The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation Type: Interventional Start Date: Dec 2021 |
Complex Adult Deformity Surgery (CADS)
International Spine Study Group Foundation
Adult Spinal Deformity
Scoliosis
Kyphosis
Sagittal Imbalance
Evaluate surgical treatment outcomes and identify best practice guidelines for complex
adult spinal deformity (ASD) patients, including radiographic and clinical outcomes,
surgical and postoperative complications, risk factors for and revision surgery rates,
and the role of standard work to improve... expand
Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications. Type: Observational [Patient Registry] Start Date: Jul 2018 |
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix
The George Washington University Biostatistics Center
Short Cervical Length
This protocol outlines a randomized trial of 630 women evaluating the use of micronized
vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth
in women carrying twins and with a cervical length of less than 30 millimeters. expand
This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of less than 30 millimeters. Type: Interventional Start Date: Nov 2015 |
Improving Adult Protective Services Client Outcomes: A Stepped-Care Social and Mental Health Engagement...
The University of Texas Health Science Center, Houston
Depression in Old Age
The purpose of this study is to ascertain the feasibility and effectiveness of an 8-week
social engagement program aimed at reducing depression and increasing social engagement
among seniors who are transitioning out of Adult Protective Services (APS) for either
elder abuse or self-neglect. expand
The purpose of this study is to ascertain the feasibility and effectiveness of an 8-week social engagement program aimed at reducing depression and increasing social engagement among seniors who are transitioning out of Adult Protective Services (APS) for either elder abuse or self-neglect. Type: Interventional Start Date: Aug 2023 |
intenSive UpPer Extremity Recovery Program for Chronic Stroke (SUPER)
The University of Texas Health Science Center, Houston
Chronic Stroke
The purpose of this study is to Investigate the feasibility of a high-quality, high-dose,
high-intensity upper extremity therapy program and to assess the treatment effects of a
high-quality, high-dose, high-intensity upper extremity therapy program on functional
outcomes, motor impairment, and quality... expand
The purpose of this study is to Investigate the feasibility of a high-quality, high-dose, high-intensity upper extremity therapy program and to assess the treatment effects of a high-quality, high-dose, high-intensity upper extremity therapy program on functional outcomes, motor impairment, and quality of life Type: Interventional Start Date: Mar 2023 |
Post Market Clinical Evaluation of Gamma 4
Stryker Trauma and Extremities
Femoral Fracture
This is a prospective, multi-center, non-randomized, post-market clinical investigation
of the Gamma 4 System. Neither subjects nor investigators are blinded to treatment.
It is anticipated that a total of 100 subjects will be enrolled at five sites. Total
duration of enrollment, 12 month follow-up... expand
This is a prospective, multi-center, non-randomized, post-market clinical investigation of the Gamma 4 System. Neither subjects nor investigators are blinded to treatment. It is anticipated that a total of 100 subjects will be enrolled at five sites. Total duration of enrollment, 12 month follow-up and analysis is expected to take approximately 30 months. The clinical investigation has been designed to follow the surgeon's standard of care for subjects treated with a cephalomedullary nail for femoral fractures or and deformities, in addition to a 12 month follow-up visit. The primary endpoint of this clinical investigation is demonstration of bone consolidation by 12 months. Type: Observational Start Date: Mar 2023 |
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
CHDI Foundation, Inc.
Huntington's Disease
Enroll-HD is a longitudinal, observational, multinational study that integrates two
former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North
America and Australasia-while also expanding to include sites in Latin America. More than
30,000 participants have now enrolled into... expand
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and biomarkers for progression and prognosis, identifying clinically-relevant phenotypic characteristics, and establishing clearly defined endpoints for interventional studies. Periodic cuts of the database are now available to any interested researcher to use in their research - visit www.enroll-hd.org/for-researchers/access-data/ to learn more. Type: Observational [Patient Registry] Start Date: Jul 2012 |
Home-based Transcranial Direct Current Stimulation (tDCS) for Behavioral Symptoms in Alzheimer's Disease...
The University of Texas Health Science Center, Houston
Alzheimer Disease
The purpose of this study is to assess acceptability, and safety of providing tDCS to
ADRD patients with behavioral symptoms and to assess the efficacy of tDCS for
ADRD-related symptoms, mainly behavioral symptoms. expand
The purpose of this study is to assess acceptability, and safety of providing tDCS to ADRD patients with behavioral symptoms and to assess the efficacy of tDCS for ADRD-related symptoms, mainly behavioral symptoms. Type: Interventional Start Date: Apr 2023 |
Effects of Pioglitazone on Stress Reactivity and Alcohol Craving
The University of Texas Health Science Center, Houston
Alcohol Use Disorder
The purpose of this study is to examine the effects of pioglitazone on stress-induced
relapse risk in a laboratory model and to examine the effects of pioglitazone on
drinking, stress/anxiety, and alcohol craving in the natural environment expand
The purpose of this study is to examine the effects of pioglitazone on stress-induced relapse risk in a laboratory model and to examine the effects of pioglitazone on drinking, stress/anxiety, and alcohol craving in the natural environment Type: Interventional Start Date: May 2022 |
Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally...
The University of Texas Health Science Center, Houston
Adults With Ulcerative Colitis
The purpose of the study is to evaluate the efficacy and safety of lyophilized
PRIM-DJ2727 capsules given orally in subjects with ulcerative colitis at remission stage.
This study will also include longitudinal analyses of recipient's gut microbiota taxonomy
and metagenomics to determine potential... expand
The purpose of the study is to evaluate the efficacy and safety of lyophilized PRIM-DJ2727 capsules given orally in subjects with ulcerative colitis at remission stage. This study will also include longitudinal analyses of recipient's gut microbiota taxonomy and metagenomics to determine potential associations with clinical outcomes in context of active FMT or placebo administration. Type: Interventional Start Date: Sep 2020 |
Solution Temperature and Fluid Deficit During Hysteroscopy
The University of Texas Health Science Center, Houston
Surgery
Hysteroscopic surgery is widely used for the treatment of gynecological diseases, such as
septum, synechiae, polyp and intrauterine fibroids. The complication rate is estimated as
0.22% and includes uterine perforation, massive bleeding, and fluid overload. Operative
hysteroscopy intravascular absorption... expand
Hysteroscopic surgery is widely used for the treatment of gynecological diseases, such as septum, synechiae, polyp and intrauterine fibroids. The complication rate is estimated as 0.22% and includes uterine perforation, massive bleeding, and fluid overload. Operative hysteroscopy intravascular absorption (OHIA) syndrome refers to fluid overload complications from operative hysteroscopies and is considered a major complication. Report describing the clinical association between irrigation fluid temperature to intravasation rate itself or the risk of fluid overload are limited mainly to theoretical models. Due to the aforementioned, we aim to evaluated the role of temperature on absorption of the irrigation solution in hysteroscopic surgery. Type: Interventional Start Date: Dec 2023 |
Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Congenital Diaphragm Hernia
Anthony Johnson
Congenital Diaphragmatic Hernia
The goal is to assess the feasibility and safety of implementing Fetoscopic Endoluminal
Tracheal Occlusion (FETO) therapy in fetuses with severe left Congenital Diaphragmatic
Hernia (CDH) at UTHealth. UTHealth's success in this study (with an initial 5 patients)
will determine the feasibility of UTHealth's... expand
The goal is to assess the feasibility and safety of implementing Fetoscopic Endoluminal Tracheal Occlusion (FETO) therapy in fetuses with severe left Congenital Diaphragmatic Hernia (CDH) at UTHealth. UTHealth's success in this study (with an initial 5 patients) will determine the feasibility of UTHealth's future participation in multi-center trials of this intervention. Type: Interventional Start Date: Dec 2015 |
Complex Abdominal, TAAA, Aortic Arch Aneurysm or Dissections With Fenestrated/Branched Stent Graft
Gustavo Oderich
Complex Abdominal Aortic Aneurysm
Thoracoabdominal Aortic Aneurysm
Aortic Arch Aneurysm
Aortic Arch Dissection
The purpose of this study is to gather safety and effectiveness of the Zenith t-Branch
and customized physician-specified stent-graft with a combination of fenestrations and/or
branches to repair aortic aneurysm. expand
The purpose of this study is to gather safety and effectiveness of the Zenith t-Branch and customized physician-specified stent-graft with a combination of fenestrations and/or branches to repair aortic aneurysm. Type: Interventional Start Date: Mar 2014 |
Nourishing the Community Through Culinary Medicine- Acres Homes
The University of Texas Health Science Center, Houston
Diabetes
Elevated Body Mass Index
The purpose of this study is to to implement adapted virtual Culinary Medicine (CM)
curriculum among target population, to assess if program participation improves
participant dietary behaviors, nutrition knowledge, and cooking skills and behaviors
above standard of care, to assess if program participation... expand
The purpose of this study is to to implement adapted virtual Culinary Medicine (CM) curriculum among target population, to assess if program participation improves participant dietary behaviors, nutrition knowledge, and cooking skills and behaviors above standard of care, to assess if program participation improves patient levels of HbA1c, Body Mass Index, Blood Pressure, HDL, LDL and Triglycerides above standard of care and to determine the feasibility and reproducibility of virtual synchronous CM classes. Type: Interventional Start Date: Nov 2023 |
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