Search Clinical Trials
Sponsor Condition of Interest |
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Cryopreserved Human Umbilical Cord as a Meningeal Patch in Fetoscopic Spina Bifida Repair
The University of Texas Health Science Center, Houston
Spina Bifida; Fetus
Myelomeningocele
Myeloschisis
The objective is to test the efficacy of a laparotomy-assisted fetoscopic surgical
approach to cover spina bifida spinal cord developmental defects using cryopreserved
human umbilical cords (NEOX Cord 1K®) as a meningeal and skin patch. expand
The objective is to test the efficacy of a laparotomy-assisted fetoscopic surgical approach to cover spina bifida spinal cord developmental defects using cryopreserved human umbilical cords (NEOX Cord 1K®) as a meningeal and skin patch. Type: Interventional Start Date: Sep 2023 |
Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia...
The University of Texas Health Science Center, Houston
Anhedonia
The purpose of this study is to investigate whether transcranial direct-current
stimulation (tDCS) will engage reward-related brain circuitry, more specifically the
uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus
accumbens (NAcc) regions. Also to evaluate... expand
The purpose of this study is to investigate whether transcranial direct-current stimulation (tDCS) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) regions. Also to evaluate whether the changes in the fractional anisotropy (FA) of the UF tract are associated with changes of clinical symptoms of anhedonia and finally to investigate the moderation role of simulated electric fields (EFs) in an association between FA of the UF and symptoms of anhedonia. Type: Interventional Start Date: Oct 2022 |
EUS-RFA PANCARDINAL-1 Trial
The University of Texas Health Science Center, Houston
Pancreatic Ductal Adenocarcinoma (PDAC)
The objectives of this study are to determine the feasibility, tolerability, and
treatment effect of endoscopic ultrasound (EUS) radiofrequency ablation (RFA) plus
standard-of-care neoadjuvant chemotherapy (NAC) in the treatment of pancreatic ductal
adenocarcinoma (PDAC). Endoscopic ultrasound (EUS)... expand
The objectives of this study are to determine the feasibility, tolerability, and treatment effect of endoscopic ultrasound (EUS) radiofrequency ablation (RFA) plus standard-of-care neoadjuvant chemotherapy (NAC) in the treatment of pancreatic ductal adenocarcinoma (PDAC). Endoscopic ultrasound (EUS) radiofrequency ablation (RFA) and neoadjuvant chemotherapy (NAC) will be performed before tumor resection surgery, with the goal of shrinking a tumor or stopping the spread of cancer so that surgery might be less invasive and more effective. Type: Interventional Start Date: Aug 2021 |
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
The George Washington University Biostatistics Center
Obstructive Sleep Apnea of Adult
Preeclampsia
Obstetrical Complications
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive
sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a
reduction in the rate of hypertensive disorders of pregnancy. expand
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy. Type: Interventional Start Date: Aug 2018 |
A Culturally Adapted, Social Support-Based, Physical Activity Interventions for South Asian Indian Women...
The University of Texas Health Science Center, Houston
Sedentary Behavior
The purpose of this study is to assess the feasibility and acceptability of a peer-based
dyadic social support health coaching physical activity (PA) intervention in inactive
South Asian Indian (SAI) and to explore preliminary effects of the intervention on
intermediate outcomes: self-reported and... expand
The purpose of this study is to assess the feasibility and acceptability of a peer-based dyadic social support health coaching physical activity (PA) intervention in inactive South Asian Indian (SAI) and to explore preliminary effects of the intervention on intermediate outcomes: self-reported and objective moderate-to-vigorous physical activity (MVPA), social support, and self-efficacy . Type: Interventional Start Date: Nov 2023 |
Pilot Study of Virtual Reality Therapy for Students With Anxiety
The University of Texas Health Science Center, Houston
Anxiety
The purpose of this study is to assess changes in self-reported anxiety over the course
of six virtual reality (VR) sessions and to assess changes in academic self-efficacy, as
well as examine the feasibility and acceptability of a relatively short and time
intensive VR intervention (i.e.,six sessions... expand
The purpose of this study is to assess changes in self-reported anxiety over the course of six virtual reality (VR) sessions and to assess changes in academic self-efficacy, as well as examine the feasibility and acceptability of a relatively short and time intensive VR intervention (i.e.,six sessions over the course of three weeks) for reducing anxiety symptoms in college students. Type: Interventional Start Date: Apr 2022 |
Combination Intraventricular Chemotherapy Pilot Study: 5-Azacytidine (5-AZA) and Trastuzumab Infusions...
The University of Texas Health Science Center, Houston
Fossa Ependymoma
The purpose of this study is to establish the safety and tolerability of simultaneous
infusions of 5-Azacytidine and trastuzumab into the fourth ventricle of the brain or
resection cavity in patients with recurrent posterior fossa ependymoma and to assess the
antitumor activity of simultaneous infusions... expand
The purpose of this study is to establish the safety and tolerability of simultaneous infusions of 5-Azacytidine and trastuzumab into the fourth ventricle of the brain or resection cavity in patients with recurrent posterior fossa ependymoma and to assess the antitumor activity of simultaneous infusions of 5-Azacytidine and trastuzumab into the fourth ventricle of the brain or resection cavity in patients based upon imaging studies and lumbar cerebrospinal fluid (CSF) cytology. Type: Interventional Start Date: Jul 2021 |
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation...
The University of Texas Health Science Center, Houston
Pain Management
The purpose of this study is to compare the effectiveness of innovative intervention of
breathing controlled electrical stimulation (BreEStim) and conventional electrical
stimulation (EStim) in management of neuropathic phantom limb pain in patients after limb
amputation after multiple sessions of... expand
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom limb pain in patients after limb amputation after multiple sessions of treatment. Type: Interventional Start Date: Apr 2021 |
A Non-invasive Intervention (BreEStim) for Management of Phantom Limb Pain (PLP) After Limb Amputation...
The University of Texas Health Science Center, Houston
Pain Management
The purpose of this study is to compare the effectiveness of innovative intervention of
breathing controlled electrical stimulation (BreEStim) and conventional electrical
stimulation (EStim) in management of neuropathic phantom limb pain in patients after limb
amputation. expand
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and conventional electrical stimulation (EStim) in management of neuropathic phantom limb pain in patients after limb amputation. Type: Interventional Start Date: Apr 2021 |
Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults With Recurrent Medulloblastoma
The University of Texas Health Science Center, Houston
Medulloblastoma
The purpose of this study is to establish the safety of infusions of panobinostat
(MTX110) into the fourth ventricle of the brain or tumor resection cavity in patients
with recurrent medulloblastoma and to assess the antitumor activity of simultaneous
infusions of panobinostat (MTX110) into the fourth... expand
The purpose of this study is to establish the safety of infusions of panobinostat (MTX110) into the fourth ventricle of the brain or tumor resection cavity in patients with recurrent medulloblastoma and to assess the antitumor activity of simultaneous infusions of panobinostat (MTX110) into the fourth ventricle of the brain or resection cavity in patients with recurrent medulloblastoma based upon MRI scans and lumbar cerebrospinal fluid (CSF) cytology. Type: Interventional Start Date: Apr 2020 |
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development...
University College, London
Huntington's Disease
HDClarity will seek at least 2500 research participants at different stages of
Huntington's disease (HD). The primary objective is to collect a high quality CSF sample
for evaluation of biomarkers and pathways that will enable the development of novel
treatments for HD. The secondary objective is... expand
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development. Type: Observational Start Date: Jan 2017 |
Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART...
National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1-infection
The purpose of this study is to evaluate the safety, tolerability, and efficacy of
therapeutic vaccination with chimpanzee adenovirus (ChAdV)- and poxvirus modified
vaccinia Ankara (MVA)-vectored conserved mosaic T-cell vaccines in a sequential regimen
with the Toll-like Receptor 7 (TLR7) agonist... expand
The purpose of this study is to evaluate the safety, tolerability, and efficacy of therapeutic vaccination with chimpanzee adenovirus (ChAdV)- and poxvirus modified vaccinia Ankara (MVA)-vectored conserved mosaic T-cell vaccines in a sequential regimen with the Toll-like Receptor 7 (TLR7) agonist vesatolimod (VES) and two broadly neutralizing antibodies (bNAbs) compared to placebo, to induce HIV-1 control during analytic treatment interruption (ATI). Type: Interventional Start Date: Apr 2024 |
Study of Tecovirimat for Human Mpox Virus
National Institute of Allergy and Infectious Diseases (NIAID)
MPOX
A5418 is a randomized, placebo-controlled, double-blind study to establish the efficacy
of tecovirimat for the treatment of people with laboratory-confirmed or presumptive HMPXV
disease. expand
A5418 is a randomized, placebo-controlled, double-blind study to establish the efficacy of tecovirimat for the treatment of people with laboratory-confirmed or presumptive HMPXV disease. Type: Interventional Start Date: Sep 2022 |
Lexion AP 50/30 Warmed Humidified Real Time CO2 Insufflation vs Airseal Recirculated CO2/Air Insufflation...
The University of Texas Health Science Center, Houston
Bariatric Surgery
The purpose of this study is to To determine the effect of warm and humidified (WH)
carbon dioxide (CO2) on post-operative pain/analgesia requirement in patients undergoing
laparoscopic bariatric surgery. expand
The purpose of this study is to To determine the effect of warm and humidified (WH) carbon dioxide (CO2) on post-operative pain/analgesia requirement in patients undergoing laparoscopic bariatric surgery. Type: Interventional Start Date: May 2023 |
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness...
LivaNova
Treatment Resistant Depression
Objectives of this study are to determine whether active VNS Therapy treatment is
superior to a no stimulation control in producing a reduction in baseline depressive
symptom severity, based on multiple depression scale assessment tools at 12 months from
randomization. expand
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization. Type: Interventional Start Date: Sep 2019 |
A Trial of the Fatty Acid Amide Hydrolase Inhibitor Palmitoylethanolamide in Bipolar Depression
The University of Texas Health Science Center, Houston
Bipolar Depression
The purpose of this study is to o evaluate the antidepressant efficacy of the PEA in
Bipolar Depression and the association between antidepressant response with endogenous
cannabinoids and cytokine levels expand
The purpose of this study is to o evaluate the antidepressant efficacy of the PEA in Bipolar Depression and the association between antidepressant response with endogenous cannabinoids and cytokine levels Type: Interventional Start Date: May 2023 |
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
University of Cincinnati
Stroke
Stroke, Acute
Stroke, Ischemic
Stroke Hemorrhagic
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute
ischemic stroke window for immediate use in clinical trials, and explore these biomarkers
in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale,
prospective dataset of clinical, transmagnetic... expand
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window. Type: Observational Start Date: Jun 2022 |
Laparoscopic Incision Closure s in Obese Patients
The University of Texas Health Science Center, Houston
Obesity
Incision, Surgical
Several methods for closure of trocar wounds are known in laparoscopic surgery including
mostly transcutaneous or subcuticular suture or adhesive paper tape. Studies comparing
laparoscopic incision closure in bariatric population are limited .This is a prospective
study that will be conducted in a... expand
Several methods for closure of trocar wounds are known in laparoscopic surgery including mostly transcutaneous or subcuticular suture or adhesive paper tape. Studies comparing laparoscopic incision closure in bariatric population are limited .This is a prospective study that will be conducted in a single tertiary medical center. s obese population comprise most of our surgical candidates, and due to the aforementioned, the aim of our study is to compare the outcomes of both techniques in obese women. Type: Interventional Start Date: Dec 2023 |
Discovery and Analytical Validation of Inflammatory Bio-signatures of the Human Pain Experience
Alan Prossin
Pain
The first objective of the study is to evaluate whether a novel bio-signature (derived
from a wide range of pro- and anti-nociceptive IL-1 family cytokine activity) will
predict pain experienced and also release of underlying endogenous opioid
neurotransmitters during an experimental nociceptive pain... expand
The first objective of the study is to evaluate whether a novel bio-signature (derived from a wide range of pro- and anti-nociceptive IL-1 family cytokine activity) will predict pain experienced and also release of underlying endogenous opioid neurotransmitters during an experimental nociceptive pain challenge, which will be performed while simultaneously quantifying mu-opioid receptor activity in the brain via [11C]-carfentanil PET neuroimaging in healthy subjects. Another objective is to evaluate whether an anti-inflammatory drug that reduces activation of IL-1b (minocycline) will perturb the balance between pro- and anti-nociceptive IL-1 cytokines and effect a reduction in pain experienced (and endogenous opioids released) during the experimental, nociceptive pain challenge. A final objective is to evaluate performance characteristics (sensitivity, accuracy, dynamic range) of the biosignature for the purpose of predicting post-operative pain. Type: Interventional Start Date: Jul 2021 |
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
Johns Hopkins University
Intracerebral Hemorrhage
This first-in-patient phase 2a pilot study will assess the safety and tolerability of
MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH). expand
This first-in-patient phase 2a pilot study will assess the safety and tolerability of MW01-6-189WH (hereafter called MW189) in patients with Intracerebral Hemorrhage (ICH). Type: Interventional Start Date: Oct 2022 |
Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach
The University of Texas Health Science Center, Houston
Neuropsychiatric Syndromes
The purpose of this research is to determine whether there is more extensive inflammation
in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood
disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse.
The research will also explore... expand
The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer [11C]PBR-28 or [11C]ER176. Type: Interventional Start Date: May 2017 |
Substance Abuse Pre-Treatment Screening Study
The University of Texas Health Science Center, Houston
Cocaine Abuse
Cocaine Dependence
Opiate Dependence
Alcohol Dependence
Substance Abuse
The overarching goal of this project is to have a consolidated consent and evaluation
procedure that will lead potential subjects to the most appropriate clinical trial or
human laboratory study (and its consent process) for their presenting concerns or
interests. A second purpose is to have a consolidated... expand
The overarching goal of this project is to have a consolidated consent and evaluation procedure that will lead potential subjects to the most appropriate clinical trial or human laboratory study (and its consent process) for their presenting concerns or interests. A second purpose is to have a consolidated intake data base on which secondary analyses can be conducted. Type: Observational Start Date: Oct 2005 |
Aerosolized Endotracheal Lidocaine to Avoid Intracranial Pressure Spikes in Patients With Severe Traumatic...
The University of Texas Health Science Center, Houston
Traumatic Brain Injury
The purpose of this study is to evaluate the effectiveness of nebulized lidocaine before
Endotracheal suctioning (ETS) compared to instilled lidocaine and the effectiveness of
aerosolized lidocaine versus instilled normal saline before ETS in attenuating the
increase of intracranial pressure (ICP)... expand
The purpose of this study is to evaluate the effectiveness of nebulized lidocaine before Endotracheal suctioning (ETS) compared to instilled lidocaine and the effectiveness of aerosolized lidocaine versus instilled normal saline before ETS in attenuating the increase of intracranial pressure (ICP) in severe head injured children and to evaluate the feasibility of a trial involving instilled lidocaine and aerosolized lidocaine for the management of ETS and to evaluate the safety of nebulized lidocaine in traumatic brain injury (TBI) compared to instilled lidocaine and instilled sodium chloride (NS). Type: Interventional Start Date: Nov 2021 |
Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex...
Boston Children's Hospital
Tuberous Sclerosis
Autism Disorder
Intellectual Disability
The purpose of this study is to characterize the developmental phenotype of ASD and ID
and to identify biomarkers using advanced MRI methodology and electrophysiological
biomarkers of synaptic function and connectivity predictive of ASD and ID presence and
severity in patients with TSC. In addition,... expand
The purpose of this study is to characterize the developmental phenotype of ASD and ID and to identify biomarkers using advanced MRI methodology and electrophysiological biomarkers of synaptic function and connectivity predictive of ASD and ID presence and severity in patients with TSC. In addition, this study will be establishing infrastructure for the collection and storage of human bio-specimens, including genetic material, from TSC patients and their family members with ASD. Type: Observational Start Date: May 2015 |
Modernizing Perinatal Syphilis Testing
The University of Texas Health Science Center, Houston
Syphilis
Treponema pallidum is a bacterium that causes the disease syphilis. The primary objective
of the study is to evaluate the testing performance of two diagnostic molecular
techniques [quantitative polymerase chain reaction (qPCR) and transcription-mediated
amplification (TMA)] for the detection of Treponema... expand
Treponema pallidum is a bacterium that causes the disease syphilis. The primary objective of the study is to evaluate the testing performance of two diagnostic molecular techniques [quantitative polymerase chain reaction (qPCR) and transcription-mediated amplification (TMA)] for the detection of Treponema pallidum in maternal and neonatal specimens from participants with the diagnosis of syphilis using the Centers for Disease Control's (CDC's) Sexually Transmitted Infections (STI) Treatment Guidelines for adult and congenital syphilis. Type: Interventional Start Date: May 2023 |
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