Search Clinical Trials
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Salud en Mis Manos - Breast and Cervical Cancer Prevention and Early Detection - Expansion 2
The University of Texas Health Science Center, Houston
Breast Cancer
Cervical Cancer
The purpose of this study is to increase early detection and prevention of breast and
cervical cancer through education and navigation and to increase breast and cervical
cancer screening and Human Papillomavirus (HPV) vaccination in underserved Latinas. expand
The purpose of this study is to increase early detection and prevention of breast and cervical cancer through education and navigation and to increase breast and cervical cancer screening and Human Papillomavirus (HPV) vaccination in underserved Latinas. Type: Interventional Start Date: Feb 2020 |
Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal...
The University of Texas Health Science Center, Houston
Anesthesia
The purpose of this study is to assess and compare conditions for tracheal intubation
obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg
succinylcholine. Specifically, the investigators will be evaluating ease of laryngoscopy,
vocal cord view, vocal cord opening,... expand
The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine. Specifically, the investigators will be evaluating ease of laryngoscopy, vocal cord view, vocal cord opening, and movement of limbs and coughing during tracheal intubation in order to assess intubation conditions, to compare efficiency and success rate of tracheal intubation between two induction agents and to determine the rate of patient awareness during induction and post-operative recall of paralysis. Type: Interventional Start Date: Sep 2023 |
Lifestyle Improvement for Teens With Bariatric Surgery
The University of Texas Health Science Center, Houston
Obesity, Adolescent
Bariatric Surgery Candidate
The purpose of this study is to Conduct a proof of concept study to assess feasibility,
acceptability, and effectiveness of an Metabolic and bariatric surgery (MBS) -supported
healthy lifestyle behavioral intervention among adolescent patients, their families, and
their clinical team. expand
The purpose of this study is to Conduct a proof of concept study to assess feasibility, acceptability, and effectiveness of an Metabolic and bariatric surgery (MBS) -supported healthy lifestyle behavioral intervention among adolescent patients, their families, and their clinical team. Type: Interventional Start Date: Mar 2022 |
The Will Erwin Headache Research Center - Cluster Headache Study
The University of Texas Health Science Center, Houston
Cluster Headache
Cluster Headaches and Other Trigeminal Autonomic Cephalgias
Paroxysmal Hemicrania
SUNCT
Hemicrania Continua
The Will Erwin Headache Research Center Study of Cluster Headache and Trigeminal
Neuralgia is a prospective, multicenter, observational research network for subjects with
Cluster Headache and/or Trigeminal Neuralgia. expand
The Will Erwin Headache Research Center Study of Cluster Headache and Trigeminal Neuralgia is a prospective, multicenter, observational research network for subjects with Cluster Headache and/or Trigeminal Neuralgia. Type: Observational Start Date: May 2016 |
High Intensity Training for Neurological Injury Using Overground Exoskeletons in Inpatient Rehabilitation
The University of Texas Health Science Center, Houston
Spinal Cord Injuries
The purpose of this study is to see if it's possible to reach high cardiovascular
intensity training parameters (exercise at a rate that elevates heart rate to the level
recommended for improving strength and endurance) while walking in a wearable robotic
exoskeleton. This study will also evaluate... expand
The purpose of this study is to see if it's possible to reach high cardiovascular intensity training parameters (exercise at a rate that elevates heart rate to the level recommended for improving strength and endurance) while walking in a wearable robotic exoskeleton. This study will also evaluate if exercising at high intensity will lead to improvement in walking ability. Participants in this study will be asked to attend 5 walking training sessions using Ekso exoskeleton. There will be two additional sessions, one before and one after the five training sessions. At these two sessions, study participants will be asked to participate in seated balance, walking speed and endurance tests and breathing assessments. Type: Interventional Start Date: Oct 2021 |
Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis
The University of Texas Health Science Center, Houston
Sepsis
Severe Sepsis
Septic Shock
Multi-organ Failure
This is an observational study to understand the changes in alveolar dead space in
medical critically ill patients with severe infection (severe sepsis) requiring
mechanical ventilation and the possibility to predict multi-organ failure.
The measurement of alveolar dead space used to require sophisticated... expand
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention. Type: Observational Start Date: Dec 2016 |
Bilirubin Neurotoxicity (BN) and Neurodevelopmental Impairment (NDI) in Extremely Preterm (EP) Infants:...
The University of Texas Health Science Center, Houston
Bilirubin Encephalopathy
The purpose of this study is to evaluate the effect of usual versus reduced lipid intake
on unbound bilirubin levels, brainstem auditory evoked responses, and neurodevelopmental
outcome at 2 years in extremely preterm infants. expand
The purpose of this study is to evaluate the effect of usual versus reduced lipid intake on unbound bilirubin levels, brainstem auditory evoked responses, and neurodevelopmental outcome at 2 years in extremely preterm infants. Type: Interventional Start Date: Jan 2021 |
ViDES Trial (Vitamin D Extra Supplementation)
The University of Texas Health Science Center, Houston
Vitamin D Deficiency
The objective of the study is to compare supplementation with vitamin D at 800 IU/day to
usual care for the first 28 days after birth with respect to 25 (OH) vitamin D levels and
indicators of likely or plausible effects of vitamin D supplementation on the function or
structure of the lung, bones,... expand
The objective of the study is to compare supplementation with vitamin D at 800 IU/day to usual care for the first 28 days after birth with respect to 25 (OH) vitamin D levels and indicators of likely or plausible effects of vitamin D supplementation on the function or structure of the lung, bones, immune system, and brain in extremely premature (EP) infants who are <28 weeks gestational age (GA) or <1000 grams of birth weight (BW). The study results will be analyzed as intention to treat Bayesian analyses (Frequentist analyses will also be performed). Type: Interventional Start Date: Sep 2022 |
Treatment of Occult Inguinal Hernias
The University of Texas Health Science Center, Houston
Inguinal Hernia
Inguinal hernias are a common surgical problem. Best management of occult inguinal
hernias, defined as hernias unable to be felt on physical exam, is unknown. From prior
studies we know that most inguinal hernias will eventually become symptomatic and require
surgery (70%). However, doing a repair... expand
Inguinal hernias are a common surgical problem. Best management of occult inguinal hernias, defined as hernias unable to be felt on physical exam, is unknown. From prior studies we know that most inguinal hernias will eventually become symptomatic and require surgery (70%). However, doing a repair on a very small, occult hernia may open the patient up to surgical complications, like chronic pain, earlier than necessary. This will be a multi-center randomized controlled trial of surgical repair versus expectant management of occult inguinal hernias. Patients undergoing laparoscopic unilateral inguinal hernia repair will be included. At the time of surgery, the surgeon will determine if there is an occult hernia contralateral side. If present, patients will be randomized to repair of the occult side or expectant management of the occult side. After 1 year post-operative data has been assessed, a decision tool will be created and administered to patients to aid in their decision making about treatments for their hernia. Type: Interventional Start Date: Oct 2021 |
MIStreatment Screening in Elders Before Discharge
The University of Texas Health Science Center, Houston
Elder Abuse
Surveys and Questionnaires
Self Neglect
Geriatrics
Geriatric Assessment
The purpose of this study is to demonstrate the feasibility of introducing, implementing,
and integrating a brief, existent elder mistreatment screening tool (the National
Collaboratory to Address Elder Mistreatment (NCAEM)'s Elder Mistreatment - Screening And
Response Tool (EM-SART) Pre-Screen) in... expand
The purpose of this study is to demonstrate the feasibility of introducing, implementing, and integrating a brief, existent elder mistreatment screening tool (the National Collaboratory to Address Elder Mistreatment (NCAEM)'s Elder Mistreatment - Screening And Response Tool (EM-SART) Pre-Screen) in the Memorial Herman Hospital (MHH)-Texas Medical Center (TMC)Acute Care of Elders(ACE) (MHH-TMC ACE) unit and to identify older adults who may already be suffering from abuse, neglect, and/or financial exploitation, as well as connecting the study participants to the primary Geriatric Medicine team on the ACE unit such that additional care, evaluation (including additional in-depth mistreatment screening), and intervention can be taken to prevent and minimize further harm prior to discharge. The investigators hope to reduce missed opportunities for mistreatment detection to lead to safer health outcomes and hospital discharges. Type: Interventional Start Date: Apr 2023 |
Ultrasound Evaluation for Improving Patient Selection in vNOTES
The University of Texas Health Science Center, Houston
Surgery
Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is an emerging field in
minimally invasive surgery. International consensus-based statement was recently
published to help guide the basis for adopting vNOTES into clinical practice, including
regarding patient selection. It was agreed... expand
Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is an emerging field in minimally invasive surgery. International consensus-based statement was recently published to help guide the basis for adopting vNOTES into clinical practice, including regarding patient selection. It was agreed that women with potential adhesions are not appropriate candidates for vNOTES approach including women with suspected adhesions due to history of severe pelvic inflammatory disease (PID) or endometriosis. However, as some pelvic infections might be asymptomatic, pre-operation imaging might be beneficial to complete improved selection of patients. Moreover, women with previous severe PID or endometriosis might still have favorable pelvic to perform the vNOTES approach. Therefore, we aim to compare pre-operation ultrasound evaluation to operative characteristics and outcomes in women undergoing VNOTES approach surgery. Type: Interventional Start Date: May 2022 |
Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity...
The University of Texas Health Science Center, Houston
Cervical Spinal Cord Injury
The purpose of this study is to determine the safety and feasibility of pairing vagus
nerve stimulation (VNS) with rehabilitation and to determine the efficacy of pairing VNS
with rehabilitation. expand
The purpose of this study is to determine the safety and feasibility of pairing vagus nerve stimulation (VNS) with rehabilitation and to determine the efficacy of pairing VNS with rehabilitation. Type: Interventional Start Date: Jul 2023 |
The Effect of a Dietary Supplement Rich in Nitric Oxide in Patients Diagnosed With Primary Ciliary Dyskinesia.
The University of Texas Health Science Center, Houston
Primary Ciliary Dyskinesia
The purpose of this study is to determine the effect of a dietary supplement rich in
nitric oxide (NO) on nasal nitric oxide and fractional exhaled nitric oxide (FeNO),on
ciliary beat frequency assessed by high-speed digital video microscopy and on lung
function assessed by spirometry in normal patients... expand
The purpose of this study is to determine the effect of a dietary supplement rich in nitric oxide (NO) on nasal nitric oxide and fractional exhaled nitric oxide (FeNO),on ciliary beat frequency assessed by high-speed digital video microscopy and on lung function assessed by spirometry in normal patients and patients with Primary ciliary dyskinesia (PCD). Type: Interventional Start Date: Jul 2019 |
7-Day Trial of Sucraid for Alleviating CSID Symptoms in Subjects With Low, Moderate, and Normal Sucrase...
QOL Medical, LLC
Congenital Sucrase-Isomaltase Deficiency
CSID
Sucrase Isomaltase Deficiency
This is a Phase 4, U.S. only, multi-center study using a 7-day therapeutic response dose
(TRD) of commercial Sucraid® to assess the response of treatment in 1100 symptomatic
pediatric (6 months to 17 years old) subjects with low, moderate, and normal sucrase
activity determined by a disaccharidase... expand
This is a Phase 4, U.S. only, multi-center study using a 7-day therapeutic response dose (TRD) of commercial Sucraid® to assess the response of treatment in 1100 symptomatic pediatric (6 months to 17 years old) subjects with low, moderate, and normal sucrase activity determined by a disaccharidase assay via EGD within 1 year of the Screening Visit. This study will also explore the relationship between known genetic CSID mutations and sucrase activities via (EGD) disaccharidase assay (low, moderate, and normal). Type: Interventional Start Date: Aug 2022 |
Artificial Intelligence (AI) Cytopathology Trial
The University of Texas Health Science Center, Houston
Pancreatic Solid Lesions
Purpose The primary objective of the study is to compare interpretation of EUS FNA/FNB
samples for adequacy between ROSE and AI at bedside. To compare accuracy of preliminary
diagnosis results between ROSE and AI at bedside versus final pathology report.
Research design This is a prospective single... expand
Purpose The primary objective of the study is to compare interpretation of EUS FNA/FNB samples for adequacy between ROSE and AI at bedside. To compare accuracy of preliminary diagnosis results between ROSE and AI at bedside versus final pathology report. Research design This is a prospective single center study to compare performance characteristics in the interpretation of EUS FNA/FNB samples between AI and ROSE. Procedures to be used Eligible patients will undergo EUS guided FNA/FNA of PSLs using standard of care. Sample slides are prepared by a cytopathologist at bedside and observed under a microscope. At the same time, the slides are scanned using a slide scanner and those images are saved for interpretation by AI at a later time. Type: Observational Start Date: Jul 2021 |
Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers
Hera Biotech, Inc.
Endometriosis
Diagnosis
This study is testing a way to diagnose endometriosis using a uterine tissue biopsy
(similar to a pap smear) as opposed to undergoing laparoscopy surgery. The tissue is sent
to lab for cellular analysis with a proprietary AI (artificial intelligence) technology. expand
This study is testing a way to diagnose endometriosis using a uterine tissue biopsy (similar to a pap smear) as opposed to undergoing laparoscopy surgery. The tissue is sent to lab for cellular analysis with a proprietary AI (artificial intelligence) technology. Type: Interventional Start Date: Sep 2022 |
CATCH Healthy Smiles:An Elementary School Oral Health Intervention Trial
The University of Texas Health Science Center, Houston
Caries,Dental
The purpose of this study is to clinically evaluate the effects of a school-based
behavioral intervention, CATCH Healthy Smiles, to reduce the risk of dental caries in a
cohort of kindergarten through 2nd grade (K-2) children serving low-income,
ethnically-diverse children,to determine the impact... expand
The purpose of this study is to clinically evaluate the effects of a school-based behavioral intervention, CATCH Healthy Smiles, to reduce the risk of dental caries in a cohort of kindergarten through 2nd grade (K-2) children serving low-income, ethnically-diverse children,to determine the impact of CATCH Healthy Smiles on child behavioral, psychosocial, and environmental outcomes beginning in K through 2nd grade, compared to children in the control schools and to examine the extent to which the child behavioral, psychosocial, and environmental factors mediate the improvements in child caries risk. Type: Interventional Start Date: Feb 2022 |
Computer Aided Polyp Detection (C3PO) Trial
The University of Texas Health Science Center, Houston
Colonic Polyp
Computer aided detection (CADe) algorithms have been developed to overcome human errors
and assist endoscopists in detecting more polyps during colonoscopy. The aim of this
study was to investigate the accuracy of the novel Pentax Discovery CADe system
(Discovery-AI) against pre-recorded videos of... expand
Computer aided detection (CADe) algorithms have been developed to overcome human errors and assist endoscopists in detecting more polyps during colonoscopy. The aim of this study was to investigate the accuracy of the novel Pentax Discovery CADe system (Discovery-AI) against pre-recorded videos of colon polyps of various size, shape and pathology while using videos of normal colon segments as controls from two different institutes. Type: Observational Start Date: Jun 2020 |
Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery?
The University of Texas Health Science Center, Houston
Quadriceps Atrophy
ACL Reconstruction
The purpose of this study is to evaluate the effectiveness of physical therapy (PT) plus
BFR training compared to PT alone (without BFR training) after ACL reconstruction in
patients who require extended limited weight bearing through assessment of patient
reported outcomes and functional testing.... expand
The purpose of this study is to evaluate the effectiveness of physical therapy (PT) plus BFR training compared to PT alone (without BFR training) after ACL reconstruction in patients who require extended limited weight bearing through assessment of patient reported outcomes and functional testing. The hypothesis is that PT plus BFR training will mitigate the loss of quadriceps muscle cross-sectional area, strength, and function while also improving early clinical and functional results. Type: Interventional Start Date: Nov 2017 |
Comparison Of Radiation Exposure To Patients During Endoscopic Retrograde Cholangiopancreatography (ERCP)...
The University of Texas Health Science Center, Houston
Pancreatic Cancer
Purpose: To compare the radiation exposure in patients during Endoscopic retrograde
cholangiopancreatography (ERCP) done by Endoscopists formally trained in judicious use of
fluoroscopy versus ERCPs done by Endoscopists without such formal training.
Research design: This is an observational study... expand
Purpose: To compare the radiation exposure in patients during Endoscopic retrograde cholangiopancreatography (ERCP) done by Endoscopists formally trained in judicious use of fluoroscopy versus ERCPs done by Endoscopists without such formal training. Research design: This is an observational study to compare radiation exposure in patients during ERCPs based on formal training. Procedures to be used: None Risks and potential benefits There are no risks associated with this study as it is a retrospective chart review. Potential benefits include the knowledge gained from this study which may be of help to patients in the future. Importance of knowledge that may reasonably be expected to result The knowledge gained from this study may be of help to provide new insights and develop newer guidelines for radiation use in the future. Type: Observational Start Date: Nov 2015 |
Mirragen Diabetic Foot Ulcer Study
The University of Texas Health Science Center at San Antonio
Diabetic Foot Ulcer
Osteomyelitis Chronic
This study is being done to collect data from treatment of patients who have diabetes
with non-healing foot wounds and are being treated with a resorbable and biocompatible
borate-based bioactive glass fiber matrix. A borate-based bioactive glass fiber matrix is
used to cover the ulcer for wound management.... expand
This study is being done to collect data from treatment of patients who have diabetes with non-healing foot wounds and are being treated with a resorbable and biocompatible borate-based bioactive glass fiber matrix. A borate-based bioactive glass fiber matrix is used to cover the ulcer for wound management. The primary objective of this study is to evaluate the safety and efficacy of the borate-based bioactive glass fiber matrix in the treatment of diabetic foot ulcers in a real-world setting. The secondary objective is to evaluate the clinical and financial benefits in terms of quality of healing, pain, and treatment cost. Type: Observational Start Date: Sep 2024 |
A Study of Sigvotatug Vedotin Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer (Be6A...
Seagen Inc.
Carcinoma, Non-Small-Cell Lung
This clinical trial is studying nonsquamous non-small cell lung cancer (NSCLC).
Participants in this study must have cancer that has spread through their body or can't
be removed with surgery. Participants in this study must have been treated with no more
than a platinum-based chemotherapy and an... expand
This clinical trial is studying nonsquamous non-small cell lung cancer (NSCLC). Participants in this study must have cancer that has spread through their body or can't be removed with surgery. Participants in this study must have been treated with no more than a platinum-based chemotherapy and an anti-PD-(L)1 drug. Participants with tumors that have certain treatable genomic alterations must have had at least 1 drug for that genomic alteration, in addition to platinum-based chemotherapy. This clinical trial uses an experimental drug called sigvotatug vedotin, which is a type of antibody drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. This clinical trial also uses a drug called docetaxel. Docetaxel is an anticancer drug that has been approved to treat non-small cell lung cancer. It is usually given to patients who previously received another anticancer treatment. In this study, one group of participants will get sigvotatug vedotin on Days 1 and 15 during each 28-day-cycle. A second group of participants will get docetaxel on Day 1 during each 21-day cycle. This study is being done to see if sigvotatug vedotin works better than docetaxel to treat participants with NSCLC. This study will also test what side effects happen when participants take these drugs. A side effect is anything a drug does to the body besides treating the disease. Type: Interventional Start Date: Feb 2024 |
GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With...
Hoffmann-La Roche
Huntington Disease
This study will evaluate the safety, biomarkers, and efficacy of tominersen compared with
placebo in participants with prodromal and early manifest Huntington's Disease expand
This study will evaluate the safety, biomarkers, and efficacy of tominersen compared with placebo in participants with prodromal and early manifest Huntington's Disease Type: Interventional Start Date: Feb 2023 |
A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting
Pfizer
Pneumonia
The purpose of this study is to learn about how well the 20-valent pneumococcal conjugate
vaccine (20vPnC) works against radiologically-confirmed community-acquired pneumonia
(RAD+CAP) due to the 7 new serotypes (types of a bacteria called Streptococcus pneumoniae
that cause pneumonia) included in... expand
The purpose of this study is to learn about how well the 20-valent pneumococcal conjugate vaccine (20vPnC) works against radiologically-confirmed community-acquired pneumonia (RAD+CAP) due to the 7 new serotypes (types of a bacteria called Streptococcus pneumoniae that cause pneumonia) included in 20vPnC vaccine. This study is seeking participants who: - are male or female ≥65 years of age. - are hospitalized with physician suspicion of community acquired pneumonia (CAP). - have pneumonia confirmed with imaging like a chest x-ray Participants will be asked to provide demographic and medical history information, and to provide a urine sample that will be used to test for pneumonia caused by specific strains of a bacteria called Streptococcus pneumoniae. We will compare the proportion of participants who have pneumonia caused by specific strains of the bacteria Streptococcus pneumoniae and were previously vaccinated with 20vPnC with the proportion of participants who have pneumonia caused by something other than vaccine type Streptococcus pneumoniae and have been vaccinated with 20vPnC. Participants will actively take part in the study for about 1-2 days. Information on participant's illness and hospitalization details will be collected through day 30 of their hospitalization through medical chart review. Type: Observational Start Date: Oct 2022 |
Glycemic Control After Antenatal Corticosteroids in Women with Pregestational and Gestational Diabetes
University of Alabama at Birmingham
Diabetes Mellitus, Type 2
Preterm Birth
Pregnancy, High Risk
Diabetes, Gestational
There is a fundamental gap in understanding the maternal and neonatal effects of
antenatal corticosteroid (ACS) administration in women with threatened preterm birth
(PTB) who have diabetes. Since the initial discovery of ACS for neonatal benefit in 1972,
more than 40 randomized controlled trials... expand
There is a fundamental gap in understanding the maternal and neonatal effects of antenatal corticosteroid (ACS) administration in women with threatened preterm birth (PTB) who have diabetes. Since the initial discovery of ACS for neonatal benefit in 1972, more than 40 randomized controlled trials have been performed evaluating its efficacy. However, none of these trials have included women with T2DM, and there is limited data among women with gestational diabetes. While ACS have been shown to reduce neonatal morbidity associated with PTB in non-diabetic women, the side effects of ACS (maternal hyperglycemia and fetal hyperinsulinemia) may mitigate the neonatal benefit of ACS in women with diabetes. Before neonatal benefit of ACS can be evaluated in this population, the first step is to optimize maternal glycemic control after ACS. Previous studies evaluating maternal hyperglycemia after ACS have been limited by small sample size, retrospective study design, or insufficient glucose data. Use of continuous glucose monitoring (CGM) in a randomized clinical trial provides a unique opportunity to overcome these challenges. Our long-term goal is to improve maternal and child health among women with diabetes as an independently funded clinical researcher. The research objectives of this proposal are to test the efficacy of three treatment strategies at achieving maternal glycemic control after ACS and evaluate the association between maternal glycemic control and neonatal outcomes. Our central hypothesis is that treatment with a continuous insulin infusion will improve maternal glycemic control, which is key to improving neonatal outcomes, but at the cost of less patient satisfaction and more health resource utilization. This hypothesis will be tested by pursuing the following specific aims: 1) Test the efficacy of three treatment strategies (addition of sliding scale insulin, up-titration of home insulin, and continuous insulin infusion) at achieving maternal glycemic control after ACS and 2) Quantify the association between maternal glycemic control after ACS and neonatal morbidity. Completion of these aims will determine the optimal strategy to achieve maternal glycemic control after ACS and inform a larger, multicenter trial to improve neonatal outcomes among women with diabetes and threatened PTB. Type: Interventional Start Date: Feb 2022 |
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