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Purpose

The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine. Specifically, the investigators will be evaluating ease of laryngoscopy, vocal cord view, vocal cord opening, and movement of limbs and coughing during tracheal intubation in order to assess intubation conditions, to compare efficiency and success rate of tracheal intubation between two induction agents and to determine the rate of patient awareness during induction and post-operative recall of paralysis.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • BMI > 30kg/m2 or Mallampati class III or IV. - Requiring general anesthesia and endotracheal intubation

Exclusion Criteria

  • Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease(COPD) and asthma. - The American Society of Anesthesiologists (ASA) physical status classification > III. - Patients requiring awake intubation. - Pregnant women. - Untreated ischemic heart disease. - Patients requiring an induction dose of propofol < 1 mg/kg. - Allergy to propofol, rocuronium, succinylcholine, or sugammadex. - Patients with renal failure and unknown potassium (K+) level, or patients with K+ level > 5.0 - Personal history of malignant hyperthermia (MH), or family history of MH - Patients with suspected or diagnosed neuromuscular disease, patients with burn injuries

Study Design

Phase
Phase 4
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Double (Participant, Investigator)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Modified Time Principle Induction (MTPI) with rocuronium
  • Drug: Modified Time Principle Induction (MTPI) with rocuronium
    Participants will be induced using lidocaine 1 mg/kg IV, an opioid such a fentanyl (1-2 mcg/kg) IV, followed by 0.6 mg/kg IV rocuronium, and IV propofol with dosage at the discretion of the care team, administered within 10 seconds of rocuronium and the intubation will be performed with a C-MAC
Active Comparator
RSI with succinylcholine
  • Drug: RSI succinylcholine
    Participants will be induced as per routine care using lidocaine 1 mg/kg IV, an opioid such a fentanyl (1-2 mcg/kg) IV, propofol 1-2 mg/kg IV, and succinylcholine 1mg/kg IV, and the intubation will be performed with a C-MAC

Recruiting Locations

The University of Texas Health Science Center at Houston
Houston, Texas 77030
Contact:
Lauren M Nakazawa, MD,MBA
713-500-6775
Lauren.M.Nakazawa@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center, Houston

Study Contact

Lauren M Nakazawa, MD,MBA
713-500-6775
Lauren.M.Nakazawa@uth.tmc.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.