Targeting EEG Markers With TMS in Cocaine Use Disorder
Purpose
The purpose of this study is to assess the effects of active intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal cortex (dmPFC) on electroencephalogram (EEG) measures of reward sensitivity and cue reactivity and cocaine craving in cocaine users
Condition
- Cocaine Use Disorder
Eligibility
- Eligible Ages
- Between 18 Years and 60 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- CUD diagnosis
Exclusion Criteria
- moderate or severe criteria for substances other than cocaine, cannabis, or nicotine - unstable psychiatric disorder - medical conditions contraindicated to TMS (e.g., medical implants, history of seizure or seizure disorder, medications lowering the seizure threshold, neurological conditions, moderate-to-severe heart disease) - pregnancy - hairstyles incompatible with the EEG net - head injury with loss of consciousness
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Care Provider)
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Experimental iTBS to dmPFC, Then Sham iTBS |
|
|
Sham Comparator Sham iTBS, Then iTBS to dmPFC |
|
Recruiting Locations
The University of Texas Health Science Center at Houston
Houston, Texas 77030
Houston, Texas 77030
More Details
- Status
- Recruiting
- Sponsor
- The University of Texas Health Science Center, Houston