Purpose

The main goal of this trial is to evaluate the safety and tolerability of mRNA-3745 via intravenous (IV) administration in adult and pediatric participants with GSD1a.

Condition

Eligibility

Eligible Ages
Over 6 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Documented GSD1a with confirmation of biallelic gene encoding glucose-6-phosphatase-α (G6PC) mutations by genetic testing. - Absence of hospitalization for hypoglycemia in the 4 weeks prior to Screening

Exclusion Criteria

  • Solid organ transplant - Received gene therapy for GSD1a - Presence of liver adenoma >5 centimeters (cm) in size - Diagnosis of type 1 or type 2 diabetes mellitus - Presence of liver adenoma with growth of >2 cm or >5 newly diagnosed liver adenomas, in the previous 2 years Note: Additional inclusion/exclusion criteria may apply, per protocol.

Study Design

Phase
Phase 1/Phase 2
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Sequential Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
SAD: mRNA-3745
Participants will receive a single intravenous (IV) dose of mRNA-3745 on Day 1 in an inpatient setting. Participants that are/have been enrolled in the study and receive an administration of mRNA-3745 may also enroll in one of the MAD cohorts. The first MAD dose must occur at least 21 days after the SAD dose.
  • Drug: mRNA-3745
    Sterile frozen liquid dispersion for injection
Experimental
MAD: mRNA-3745
Participants will receive multiple IV doses of mRNA-3745 in an inpatient setting. Participants will have the option to continue treatment in the OLE.
  • Drug: mRNA-3745
    Sterile frozen liquid dispersion for injection

Recruiting Locations

The University of Texas Health Science Center at Houston
Houston, Texas 77030-1501
Contact:
713-500-7098
heather.saavedra@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
ModernaTX, Inc.

Study Contact

Moderna Clinical Trials Support Center
1-877-777-7187
clinicaltrials@modernatx.com

Detailed Description

The study includes a single ascending dose (SAD) stage and a multiple ascending dose (MAD) stage. Participants enrolled in the MAD stage have the option to continue treatment in an open-label extension (OLE) period that will assess long-term safety and clinical activity of mRNA-3745.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.