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Purpose

The purpose of this study to determine the therapeutic response of non-allergic rhinitis patients that have been subtyped as non-allergic rhinitis with local IgE elevation or non-allergic rhinopathy to intranasal capsaicin based on visual analog scale and optical rhinometry, to determine the prevalence of non-allergic rhinitis with local IgE elevation in this study's cohort of patients with non-allergic rhinitis identified by rhinitis history and negative skin testing for allergic rhinitis, and to determine the change, if any, in intranasal IgE levels after capsaicin treatment.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Chronic rhinitis

Exclusion Criteria

  • Active smoker - Anatomic source of nasal symptoms - Chronic rhinosinusitis or other nasal infection - History of sinonasal malignancy - Pregnancy or lactation - Use of medication affecting nasal function (topical steroids, topical anticholinergics, oral antihistamines) in the previous 4 weeks - Use or abuse of nasal decongestants. - Positive skin prick test for allergic rhinitis

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Treatment
  • Drug: Intranasal capsaicin
    Intranasal capsaicin, 5 applications each delivering 2 micrograms in each nostril, separated by 1 hour.
  • Drug: topical lidocaine
    The nose will be pre-treated with topical lidocaine 15 minutes before each application

Recruiting Locations

The University of Texas Health Science Center at Houston
Houston, Texas 77030
Contact:
Kunal R Shetty, MD
713-486-5000
Kunal.R.Shetty@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center, Houston

Study Contact

Kunal R Shetty, MD
(713) 486-5000
Kunal.R.Shetty@uth.tmc.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.