Purpose

The purpose of this study is to determine the feasibility and impact of 28-days of monitored abstinence from cannabis use on symptoms of depression and anxiety, pain, sleep, cannabis use withdrawal, HIV viral load and biomarkers of systemic inflammation among PLWH and who use cannabis regularly (weekly or more often). This will be a single arm pilot feasibility trial involving a contingency management program to induce cannabis abstinence. Specifically, the contingency management program will provide motivational (monetary) incentives to participants who achieve biochemically verified cannabis abstinence. Over the 28-days of this pilot feasibility trial, participants will attend seven study visits. During these visits, participants will complete survey questionnaires to assess sociodemographic, psychosocial, and behavioral factors. In addition, participants will provide blood and urine specimens for testing and quantitation of HIV viral load, biomarkers of systemic inflammation and for the detection of cannabis and other drugs of abuse.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • HIV-positive (confirmed via HIV medication or relevant HIV labs in subject's name) - Self-report of cannabis use at least once per week in the 6-month period prior to consent - Provide a positive urine toxicology (UTOX) screen for cannabis - Not seeking treatment for cannabis use - Willing to stop using cannabis for 28 days and attend eight study visits over six weeks. - Ability and willingness to provide inform consent - English fluency

Exclusion Criteria

  • Currently receiving treatment for cannabis or other drug use disorder - Diagnosed or receiving treatment for a current major depressive or anxiety disorder - Diagnosed with any current alcohol or substance use disorder (excluding nicotine) using the Structured Clinical Interview for Clinical Disorders (SCID) Interview (22) - Positive UTOX screen for opioids - Having a medical, psychiatric, occupational, or other condition that, in the judgment of the study physician, would make participation difficult or unsafe.

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Other
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Contingency Management - Cannabis
Participants will be incentivized following biochemical verification (from urine samples) of cannabis abstinence.
  • Behavioral: Contingency Management - Cannabis
    Participants in the contingency management program will be provided financial incentives for 28-days of cannabis abstinence. At every visit, participants will provide urine samples for the biochemical verification of cannabis abstinence). Participants with evidence of cannabis abstinence will be provided a financial incentive that increases across subsequent study visits.

Recruiting Locations

Center for Neurobehavioral Research on Addiction
Houston, Texas 77054
Contact:
Rolanda Johnson
713-486-2823
rolanda.johnson@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
Baylor University

Study Contact

Chukwuemeka N Okafor, PhD, MPH
857-225-3923
emeka_okafor@baylor.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.