The purpose of the study is to evaluate of the relationships between fractionated exhaled nitric oxide, disease activity, and symptom severity in patients with eosinophilic esophagitis compared to those without eosinophilic esophagitis.



Eligible Ages
Between 5 Years and 18 Years
Eligible Genders
Accepts Healthy Volunteers

Inclusion Criteria

  • Pediatric patient who will undergo esophagogastroduodenoscopy with biopsies at Children's Memorial Hermann Hospital, as part of the standard of care in the evaluation of EoE
  • Able to perform the single-breath exhalation for the hand-held analyzer, "NIOX VERO┬«" (Aerocrine, Sweden)
  • Signed informed consent by a parent or legal guardian
  • Signed assent form by the child/adolescent subjects 7-18 years of age

Exclusion Criteria

  • Past medical history of asthma, allergic rhinitis, IBD, parasitic infection, hay fever and any exposure to smoking (including secondhand smoke) because these disorders are known to affect the FeNO levels
  • Active respiratory tract infections at the time of FeNO evaluation because this can affect the result of the FeNO as well
  • Asthma questionnaire and/or Spirometry test consistent with asthma

Study Design

Study Type
Observational Model
Time Perspective

Arm Groups

ArmDescriptionAssigned Intervention
Active eosinophilic esophagitis
Eosinophilic esophagitis in remission
No eosinophilic esophagitis

Recruiting Locations

The University of Texas Health Science Center at Houston
Houston, Texas 77030

More Details

The University of Texas Health Science Center, Houston

Study Contact

Cristoniel Abrenica, MD
(713) 500-5663


Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.