Purpose

This is a Phase 1/2a open label study to evaluate the safety, tolerability, pharmacokinetics and anti-viral activity of PGT121, VRC07-523LS and PGDM1400 for HIV prevention and therapy.

Condition

Eligibility

Eligible Ages
Between 18 Years and 65 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

for HIV-uninfected volunteers (Group 1): 1. Healthy male or female, including transgender, volunteers, as assessed by a medical history, physical exam, and laboratory test 2. At least 18 years of age on the day of screening and has not reached his or her 51st birthday on the day of signing the Informed Consent Document 3. Willing to undergo HIV testing, risk reduction counseling and receive HIV test results 4. Low risk for HIV infection for 12 months prior to study participation and willing to maintain low-risk behavior for the duration of the trial Specific inclusion criteria for HIV-infected volunteers (Group 2): 1. At least 18 years of age on the day of screening and has not reached his or her 66th birthday on the day of signing the Informed Consent Document 2. Confirmed HIV-1 infection (HIV Ab+ or HIV RNA+) by documentation in the medical records or in-clinic HIV testing 3. CD4 ≥ 400 cells/µl 4. On antiretroviral therapy for a minimum of 24 months, with plasma HIV-1 RNA levels of < 50 copies/ml for at least 12 months as documented in the medical records, and with a viral load < 50 copies / ml at time of screening (within 56 days prior to IP administration). ART must not have been initiated during the acute phase of the infection as suggested by the available medical history and laboratory data from the time of the diagnosis. Note: ART is defined as a regimen including > 2 compounds, e.g., 2x nucleoside reverse transcriptase inhibitors plus either non-nucleoside reverse transcriptase inhibitor or protease inhibitor or integrase inhibitor. 5. If on an NNRTI-based regimen, willing to switch to an integrase inhibitor containing regimen for 4 weeks prior to discontinuing ART 6. No history of AIDS-defining illness within the past 5 years 7. No history of CD4 nadir <200 cells/ul 8. Under care of an HIV healthcare provider 5.6

Exclusion Criteria

Exclusion criteria for all volunteers: 1. Any clinically significant acute or chronic medical condition, other than HIV infection, that is considered progressive or in the opinion of the investigator makes the volunteer unsuitable for participation in the study. 2. Any clinically relevant abnormality on history or examination including history of immunodeficiency (other then HIV infection) or autoimmune disease; use of systemic corticosteroids, immunosuppressive, anticancer, or other medications considered significant by the investigator within the previous 6 months. The following exceptions are permitted and will not exclude study participation: use of corticosteroid nasal spray for rhinitis, topical corticosteroids for an acute uncomplicated dermatitis; or a short course (duration of 10 days or less, or a single injection) of corticosteroid for a non-chronic condition (based on investigator clinical judgment) at least 6 weeks prior to enrollment in this study. 3. If born female, pregnant, lactating or planning a pregnancy during the period of screening through completion of the study. 4. In the past 6 months a history of alcohol or substance use, including marijuana, judged by the Investigator to potentially interfere with volunteer study compliance. 5. Bleeding disorder that was diagnosed by a physician. Note: A volunteer who states that he or she has easy bruising or bleeding, but does not have a formal diagnosis and has intramuscular injections and blood draws without any adverse experience, is eligible. 6. History of a splenectomy. 7. Receipt of live attenuated vaccine within the previous 30 days or planned receipt within 30 days after administration of investigational product; or receipt of other vaccine within the previous 14 days or planned receipt within 14 days after infusion with investigational product (exception is live attenuated influenza vaccine within 14 days). 8. Receipt of blood transfusion or blood-derived products within the previous 3 months. 9. Participation in another clinical trial of an investigational product currently, within the previous 3 months or expected participation during this study. Note: receipt of placebo in a clinical trial in the previous 3 months will not exclude a volunteer from participation if documentation is available and the Medical Monitor gives approval. 10. Prior receipt of an investigational HIV vaccine candidate, monoclonal antibody or polyclonal immunoglobulin. Note: receipt of placebo in a previous HIV vaccine or monoclonal antibody trial will not exclude a volunteer from participation if documentation is available and the Medical Monitor gives approval. 11. History of severe local or systemic reactogenicity to injections or IV infusion (e.g., anaphylaxis, respiratory difficulties, angioedema). 12. Psychiatric condition that compromises safety of the volunteer and precludes compliance with the protocol. Specifically excluded are persons with psychoses within the past 3 years, ongoing risk for suicide, or history of suicide attempt or gesture within the past 3 years. 13. If, in the opinion of the Principal Investigator, it is not in the best interest of the volunteer to participate in the trial. 14. Seizure disorder: a volunteer who has had a seizure in the last 3 years is excluded. 15. Body mass index ≥ 35 or ≤ 18.5. 16. Infectious disease: chronic hepatitis B infection (HbsAg), current hepatitis C infection (HCV Ab positive and HCV RNA positive) or interferon-alfa treatment for chronic hepatitis C infection in the past year, chlamydia, gonorrhea, or active syphilis. 17. A history of malignancy within the past 5 years (prior to screening) or ongoing malignancy (exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situ of the cervix, or malignancy, which is considered cured with minimal risk of recurrence) 18. Active, serious infections (other than HIV-1 infection) requiring parenteral antibiotic, antiviral or antifungal therapy within 30 days prior to enrollment. 19. Any of the following abnormal laboratory parameters listed below: Hematology - Hemoglobin < 10.5 g/dL in females; hemoglobin <11.0 g/dL in males - Absolute Neutrophil Count (ANC): ≤ 1000/mm3 - Platelets: < 100,000 mm3 or ≥ 550,000/mm3 Chemistry - AST ≥ 1.5 x ULN - ALT ≥ 1.5 x ULN - Total bilirubin ≥ 1.1 x ULN - Alkaline phosphatase ≥ 1.5 x ULN - Albumin ≤ 3.0 g/dL (equivalent to ≤ 30 g/L) - Estimated Glomerular filtration rate (GFR) < 60 ml/min according to the Cockcroft Gault formula for creatinine clearance - Male: (140 - age in years) x (wt in kg) = CLcr (ml/min) / 72 x (serum creatinine in mg/dL) - Female: (140 - age in years) x (wt in kg) x 0.85 = CLcr (mL/min) / 72 x (serum creatinine in mg/dL) Urinalysis: Any of the following abnormal findings if consistent with clinically significant disease: - Protein = 2+ or more - Blood = 2+ or more (not due to menses) Specific exclusion criteria for HIV-uninfected volunteers (Group 1): 1. Confirmed HIV-1 infection

Study Design

Phase
Phase 1/Phase 2
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Other
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Group 1A
HIV-uninfected volunteers receiving one IV infusion
  • Biological: PGT121 + VRC07-523LS
    PGT121 + VRC07-523LS, dose 30 mg/kg each, given intravenously
Active Comparator
Group 1B
HIV-uninfected volunteers receiving one IV infusion
  • Biological: PGT121 + VRC07-523LS + PGDM1400
    PGT121 + VRC07-523LS + PGDM1400, dose 20 mg/kg each, given intravenously
Active Comparator
Group 2
HIV-infected volunteers on ART receiving three or six IV infusions
  • Biological: PGT121 + VRC07-523LS + PGDM1400
    PGT121 + VRC07-523LS + PGDM1400, dose 20 mg/kg each, given intravenously

More Details

Status
Completed
Sponsor
International AIDS Vaccine Initiative

Study Contact

Detailed Description

This is a Phase 1/2a open label study to evaluate the safety, tolerability, pharmacokinetics and anti-viral efficacy of PGT121, VRC07-523LS and PGDM1400 antibodies for HIV prevention and therapy. PGT121, VRC07-523LS and PGDM1400 are recombinant human IgG1 monoclonal antibodies that target a V3 glycan-dependent epitope region of the HIV envelope protein and the CD4 binding site (CD4bs) of the HIV envelope protein. PGT121, VRC07-523LS and PGDM1400 mAbs were chosen for this study because of their potency, their ability to neutralize a wide array of cross-clade HIV viruses in a complementary pattern, and their proven antiviral activity in animal studies, e.g., their capacity to robustly prevent and treat simian-human immunodeficiency virus (SHIV) in rhesus monkeys. The potency and breadth of PGT121, VRC07-523LS and PGDM1400 raise the possibility that monoclonal antibodies may be effective for HIV prophylaxis at low doses and against global viruses. Neutralization sensitivity profiles are complementary; and the combination of these mAbs with unique epitope specificities will provide experience assessing the potential additive, synergistic, or antagonistic properties of two bNAbs given sequentially.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.