Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
Purpose
The purpose of this study is to compare the level of pain control in patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) to those receiving opioids in the postoperative period after endoscopic sinus surgery (ESS) and/or septoplasty.
Condition
- Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- english speaking - candidates for endoscopic sinus surgery as determined by medical necessity by the treating rhinologist - scheduled for surgery at Texas Sinus Institute
Exclusion Criteria
- allergy to either NSAIDs or opioids - contraindication to NSAIDs (ex. gastritis, chronic kidney disease) - surgical plan exceeding basic endoscopic sinus surgery - use of anticoagulation - the presence of any pain disorder - the current usage of any analgesic medication - history of opioid addiction - pregnancy - history of chronic pain or fibromyalgia - current daily use of NSAIDs, acetaminophen, opioids or other analgesics (pregabalin, tramadol, etc)
Study Design
- Phase
- Phase 4
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental NSAID |
The non-steroidal anti-inflammatory drug (NSAID) used in this study is diclofenac. |
|
|
Active Comparator opioid |
The Opioid used in this study is Norco. Norco is a combination medication that contains both an opioid pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). |
|
More Details
- Status
- Completed
- Sponsor
- The University of Texas Health Science Center, Houston