Purpose

The primary objective of the study is to determine the safety of single doses of DTX401, including the incidence of dose-limiting toxicities (DLTs) at each dose level.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Males and females ≥18 years of age
  • Documented GSDIa with confirmation by molecular testing
  • Documented history of ≥1 hypoglycemic event with blood glucose <60 mg/dL (<3.33 mmol/L)
  • Patient's GSDIa disease is stable as evidenced by no hospitalization for severe hypoglycemia during the 4-week period preceding the screening visit

Exclusion Criteria

  • Anti-AAV8 neutralizing antibody titer ≥1:5
  • Screening or Baseline (Day 0) blood glucose level <60 mg/dL (<3.33 mmol/L)
  • Liver transplant, including hepatocyte cell therapy/transplant
  • Presence of liver adenoma >5 cm in size
  • Presence of liver adenoma >3 cm and ≤5 cm in size that has a documented annual growth rate of ≥0.5 cm per year
  • Significant hepatic inflammation or cirrhosis as evidenced by imaging or any of the following laboratory abnormalities: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > upper limit of normal (ULN), total bilirubin >1.5 × ULN, alkaline phosphatase >2.5 × ULN

Note additional inclusion/exclusion criteria may apply, per protocol.

Study Design

Phase
Phase 1/Phase 2
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
DTX401 Dose 1
DTX401 solution for intravenous (IV) infusion
  • Genetic: DTX401
    DTX401 administered as a single peripheral IV infusion
    Other names:
    • AAV8G6PC
Experimental
DTX401 Dose 2
DTX401 solution for intravenous (IV) infusion
  • Genetic: DTX401
    DTX401 administered as a single peripheral IV infusion
    Other names:
    • AAV8G6PC
Experimental
DTX401 Dose 3
DTX401 solution for intravenous (IV) infusion
  • Genetic: DTX401
    DTX401 administered as a single peripheral IV infusion
    Other names:
    • AAV8G6PC

Recruiting Locations

UT Health - McGovern Medical School
Houston, Texas 77030

More Details

NCT ID
NCT03517085
Status
Recruiting
Sponsor
Ultragenyx Pharmaceutical Inc

Study Contact

Patients Contact: Patient Advocacy
1-415-483-8800
patientadvocacy@ultragenyx.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.