Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean
Purpose
A randomized placebo-controlled trial of 11,000 women to assess whether tranexamic acid as prophylaxis lowers the risk of postpartum hemorrhage in women undergoing a cesarean delivery.
Conditions
- Obstetrical Complications
- Hemorrhage
- Labor and Delivery
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Scheduled or unscheduled cesarean delivery 2. Singleton or twin gestation
Exclusion Criteria
- Age less than 18 years 2. Transfusion or planned transfusion of any blood products during the current admission because the primary outcome is already pre-determined and the need for transfusion will be unrelated to perioperative hemorrhage 3. Recent diagnosis or history of venous thromboembolism or arterial thrombosis because TXA is a risk factor for thromboembolism, and its use is contraindicated 4. Known congenital or acquired thrombophilias, including antiphospholipid antibody syndrome, because of the increased risk of thrombosis 5. Seizure disorder (including eclampsia) because TXA is a GABA receptor antagonist, and its use has been associated with postoperative seizures 6. Serum creatinine 1.2 or higher or on dialysis, with renal disease, or a history of renal insufficiency, because TXA is substantially excreted by the kidney, and impaired renal function may increase the risk of toxic reactions. 7. Sickle cell disease, because of substantial use of perioperative transfusion unrelated to hemorrhage. Sickle cell trait is not an exclusion per se. 8. Autoimmune diseases such as lupus, rheumatoid arthritis, Sjogren's disease, and inflammatory bowel disease because of hypercoagulability and the increased risk of thrombosis or thromboembolism 9. Need for therapeutic dose of anticoagulation before delivery, because the risk of thrombosis may be increased with TXA 10. Treatment with clotting factor concentrates, because the risk of thrombosis may be increased with TXA 11. Presence of frank hematuria, because the risk of ureteral obstruction in those with upper urinary tract bleeding may be increased with TXA 12. Patient refusal of blood products because the primary outcome is then pre-determined 13. Receipt of TXA; or planned or expected use of TXA prophylaxis 14. Active cancer, because of risk of thromboembolism 15. Congestive heart failure requiring treatment, because of risk of thrombosis 16. History of retinal disease, because the risk of central retinal artery or vein obstruction may be increased with TXA 17. Acquired defective color vision or subarachnoid hemorrhage, since TXA is contraindicated 18. Hypersensitivity to TXA or any of the ingredients 19. No hemoglobin result available from the last 4 weeks, since it is necessary to measure the post-operative change in hemoglobin 20. Scheduled cesarean delivery and quota for scheduled deliveries already met. Quotas on the number of scheduled and unscheduled deliveries will be placed to ensure approximately equal distribution of scheduled and unscheduled cesarean deliveries. 21. Participation in this trial in a previous pregnancy. Patients who were screened in a previous pregnancy, but not randomized, may be included. 22. Participating in another intervention study where the primary outcome includes postpartum bleeding or thromboembolism, or the study intervention directly affects postpartum bleeding or thromboembolism 23. Receipt of uterotonics, other than oxytocin, or planned or expected use of uterotonic prophylaxis 24. Symptomatic for COVID-19 infection within 14 days prior to delivery
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Intervention Model Description
- Participants will be randomized to receive either TXA (1 gram [10cc] mixed with 40 cc of normal saline) administered intravenously or a placebo control of 50 cc of normal saline administered intravenously
- Primary Purpose
- Prevention
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Masking Description
- The patient nor the clinical staff will be aware of the treatment assignment. The TXA or placebo solutions will be prepared by the center research pharmacies.
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Tranexamic Acid |
Tranexamic Acid for intravenous administration |
|
|
Placebo Comparator Placebo |
Normal saline for intravenous administration |
|
More Details
- Status
- Completed
- Sponsor
- The George Washington University Biostatistics Center
Study Contact
Detailed Description
Obstetrical hemorrhage is a common cause of maternal morbidity and mortality worldwide. The frequency and severity of hemorrhage is significantly higher after cesarean delivery than vaginal delivery. Recent evidence has emerged about the importance of the fibrinolytic pathway in the pathophysiology of hemorrhage in different clinical scenarios including trauma-associated bleeding, cardiovascular surgery, and obstetrical hemorrhage. Tranexamic acid (TXA) inhibits fibrinolysis and is used routinely to prevent hemorrhage in trauma cases and high risk surgeries. Randomized trials of TXA as a prophylaxis to prevent hemorrhage in cesarean delivery have been small and of mixed quality; however meta-analysis suggests that it is effective. This study is a randomized placebo-controlled trial of 11,000 women to assess whether tranexamic acid as prophylaxis lowers the risk of postpartum hemorrhage in women undergoing a cesarean delivery.