Network Effects of Therapeutic Deep Brain Stimulation

Purpose

The purpose of this study is to map the acute, short-term cortical evoked responses to thalamic electrical stimulation in persons with intractable epilepsy

Condition

  • Intractable Epilepsy

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • diagnosis of Epilepsy - undergoing neuromodulation therapy with clinically implanted neuromodulation devices (DBS, RNS) - followed in the outpatient epilepsy clinic

Exclusion Criteria

  • pregnant women - active psychosis, major depression, or suicidal ideation in the preceding year - Intelligence quotient (IQ) less than 70 as measured by clinical neuropsychological evaluation - Do not agree to share their medical records for research purposes

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Basic Science
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Treatment
  • Device: RNS/DBS activation
    This will be performed to study the EEG responses to DBS/RNS stimulation electrical pulses. The stimulation frequencies will be sequentially increased and each stimulation will last for 2 minutes.There will be a 1-2 minute wash out period after each trial.

Recruiting Locations

The University of Texas Health Science Center at Houston
Houston, Texas 77030
Contact:
Sandipan Pati, MD
713-500-7925
Sandipan.Pati@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center, Houston

Study Contact

Sandipan Pati, MD
713-500-7925
Sandipan.Pati@uth.tmc.edu