Home-based Transcranial Direct Current Stimulation for Pain Management in Persons With Alzheimer's Disease and Related Dementias
Purpose
The purpose of this project is to evaluate the preliminary effects of home-based M1-SO applied tDCS (that is, tDCS with the anode over the primary motor cortex and the cathode over the contralateral supraorbital area) on clinical pain in persons with early-stage Alzheimer's disease and Related Dementias (ADRD), to evaluate the preliminary effects of home-based M1-SO applied tDCS on pain-related cortical response in persons with early-stage ADRD, and to evaluate the feasibility and acceptability of home-based M1-SO applied tDCS for pain management in persons with early-stage AD.
Condition
- Alzheimer's Disease and Related Dementias
Eligibility
- Eligible Ages
- Between 50 Years and 90 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- early-stage Alzhimer's disease and related dementias (ADRD) - have caregiver-reported chronic pain (average pain in the past 3 months ≥ 3 out of 10), - have a caregiver willing to participate in the study who sees the participant at least 10 hours/week - can speak and read English - have no plans to change medication regimens during the trial
Exclusion Criteria
- history of brain surgery, brain tumor, seizure, stroke, or intracranial metal implantation - alcohol/substance abuse - severely diminished cognitive function (i.e., MiniMental Status Exam score ≤ 15) - hospitalization within the preceding year for neuropsychiatric illness
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Care Provider)
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Experimental Active tDCS |
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Placebo Comparator Sham tDCS |
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More Details
- Status
- Completed
- Sponsor
- Florida State University