Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation

Purpose

To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.

Condition

  • Intractable Epilepsy

Eligibility

Eligible Ages
Between 0 Days and 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Children diagnosis with Intractable Epilepsy

Exclusion Criteria

  • No Intractable Epilepsy

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Diagnostic
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Observational cohort
Observing MRI changes in subjects.
  • Procedure: Observation
    Observation of MRI changes in subjects

Recruiting Locations

UTHealth & Children's Memorial Hermann Hospital
Houston, Texas 77030
Contact:
Manish N Shah, M.D.
713-500-7410
Manish.N.Shah@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center, Houston

Study Contact

Manish N Shah, M.D.
713 500-7410
Manish.N.Shah@uth.tmc.edu

Detailed Description

To determine if diffusion tensor and functional connectivity magnetic resonance imaging helpful to better understand and diagnose intractable epilepsy in children. All enrolled children will undergo standard preoperative and postoperative MRI imaging, plus a 15 minute set of functional connectivity and diffusion tensor sequence with no additional sedation. This imaging data will be stripped of identifiers and be processed to provide both quantitative analysis, resting state functional connectivity changes and three dimensional modeling of white matter tracts adjacent to epileptogenic foci. This study is being done to determine if diffusion tensor and functional connectivity magnetic resonance imaging are helpful to better understand and diagnose intractable epilepsy in children.