Substance Abuse Pre-Treatment Screening Study

Purpose

The overarching goal of this project is to have a consolidated consent and evaluation procedure that will lead potential subjects to the most appropriate clinical trial or human laboratory study (and its consent process) for their presenting concerns or interests. A second purpose is to have a consolidated intake data base on which secondary analyses can be conducted.

Conditions

  • Cocaine Abuse
  • Cocaine Dependence
  • Opiate Dependence
  • Alcohol Dependence
  • Substance Abuse

Eligibility

Eligible Ages
Between 18 Years and 60 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Willing and able to participate in 3- to 6-month treatment program. - At least 18 years of age. - Seeking treatment for substances of abuse including (cocaine, opiates, and alcohol). - Generally physically healthy.

Exclusion Criteria

  • Pregnant or breastfeeding. - Mandated by the courts/parole officers to attend treatment. - Not seeking treatment for substances of abuse. - Plans to move from the Houston area within the 3- to 6-month treatment period. - Seeking treatment for a substance for which the Treatment Research Clinic (TRC) has no current trial.

Study Design

Phase
Study Type
Observational
Observational Model
Other
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
A Cocaine Dependent Subjects
  • Drug: modafinil
    400 mg daily
    Other names:
    • Provigil
  • Drug: d-amphetamine
    60mg daily
    Other names:
    • Dexedrine
  • Drug: L-Dopa
    800/200mg daily
    Other names:
    • Sinemet
  • Drug: Naltrexone
    50mg daily
    Other names:
    • Revia

Recruiting Locations

University of Texas Medical School- Houston, Dept. of Psychiatry Mental Sciences Institute
Houston, Texas 77054
Contact:
Rolanda Johnson, MA
713-486-2823
Rolanda.Johnson@uth.tmc.edu

More Details

Status
Recruiting
Sponsor
The University of Texas Health Science Center, Houston

Study Contact

Jessica Vincent, BS
713-486-2803
Jessica.N.Vincent@uth.tmc.edu

Detailed Description

Approximately 1500 candidates per year will respond to advertisements and will complete preliminary telephone screening without identifiers. Appropriate candidates will be given appointment times and on arrival will undergo the consent process for evaluation. A complete medical, social, psychiatric, and drug use history will be obtained. Subjects fulfilling general health inclusion requirements will then be offered an appropriate study for which the specific consent will be obtained. The evaluation period will be no more than one day with all results evaluated within the two following days. Acceptable candidates will then be invited to complete the study specific consent.