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Developing a Culturally Adapted Intervention for Latino Youth Transitioning to Adulthood
The University of Texas Health Science Center, Houston
Autism Spectrum Disorder
The purpose of this study is to evaluate the acceptability, feasibility (e.g.,
satisfaction, completion rate, barriers to recruitment, treatment fidelity) of the
culturally refined Launching! to Adulthood (¡Iniciando! la Adultez) program, to test for
a preliminary signal of effect between baseline1 expand
The purpose of this study is to evaluate the acceptability, feasibility (e.g., satisfaction, completion rate, barriers to recruitment, treatment fidelity) of the culturally refined Launching! to Adulthood (¡Iniciando! la Adultez) program, to test for a preliminary signal of effect between baseline and post-treatment for the Launching! to Adulthood (¡Iniciando! la Adultez) program and to identify preliminary neural mechanisms of action, including biomarkers of brain structure and connectivity, in terms of treatment response for 15 Latino young adults participating in the ¡Iniciando! therapy program. Type: Interventional Start Date: Apr 2024 |
Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and S1
The University of Texas Health Science Center, Houston
HIV Infections
The purpose of this study is to determine whether Motivating Youth to Reduce Infections,
Disconnections, and Emotion dysregulation (MY-RIDE) decreases substance use , to
determine whether MY-RIDE increases human immunodeficiency virus (HIV) prevention
strategies and to evaluate MY-RIDE effects on w1 expand
The purpose of this study is to determine whether Motivating Youth to Reduce Infections, Disconnections, and Emotion dysregulation (MY-RIDE) decreases substance use , to determine whether MY-RIDE increases human immunodeficiency virus (HIV) prevention strategies and to evaluate MY-RIDE effects on willingness to take Pre-Exposure Prophylaxis (PrEP), stress, substance use urge, and use of mental health and substance use services when compared to attention control youth Type: Interventional Start Date: Nov 2024 |
Pilot Feasibility Trial of the SafeLM Supraglottic Airway (SGA)
The University of Texas Health Science Center, Houston
Anesthesia
The purpose of this study is to assess the feasibility of SafeLM as a primary airway
device and as a conduit for intubation with and without the use of a bougie expand
The purpose of this study is to assess the feasibility of SafeLM as a primary airway device and as a conduit for intubation with and without the use of a bougie Type: Interventional Start Date: Sep 2023 |
PRIME: PReservIng Memory in Epilepsy
Nitin Tandon
Mesial Temporal Lobe Epilepsy
In this study, participants will receive unilateral Deep Brain Stimulation (DBS) for
treatment of epilepsy, with network-based stimulation targets specifically defined using
a stereo-electro-encephalographic evaluation and chronic recordings using the Medtronic
Percept™ primary cell (PC) Neurostimu1 expand
In this study, participants will receive unilateral Deep Brain Stimulation (DBS) for treatment of epilepsy, with network-based stimulation targets specifically defined using a stereo-electro-encephalographic evaluation and chronic recordings using the Medtronic Percept™ primary cell (PC) Neurostimulator DBS System with BrainSense™ Technology. The hypothesis is that, compared to no stimulation or to standard duty cycle high frequency stimulation, epilepsy neuromodulation using low frequency stimulation and informed by network architecture in patients with epilepsy that arises in a hippocampus that also subserves memory - epilepsy in a precious hippocampus (EPH) - will result in a significant decrease in seizure frequency and severity, paralleled by a decrease in EEG spike counts and improved memory function. Type: Interventional Start Date: Nov 2023 |
Endovascular Engineering ENGULF Study
Endovascular Engineering
Pulmonary Embolism
Evaluation of initial safety and clinical feasibility of the Hēlo PE Thrombectomy System
for thrombectomy in acute submassive pulmonary embolism (PE). expand
Evaluation of initial safety and clinical feasibility of the Hēlo PE Thrombectomy System for thrombectomy in acute submassive pulmonary embolism (PE). Type: Interventional Start Date: Jan 2023 |
Comparing Tissue Adhesives in Port Site Closure
The University of Texas Health Science Center, Houston
Dermatitis, Contact
This is a multi-center randomized controlled trial to evaluate two different methods of
reinforcing surgical port site closure: 2-Octylcyanoacrylate and n-butyl-2-cyanoacrylate. expand
This is a multi-center randomized controlled trial to evaluate two different methods of reinforcing surgical port site closure: 2-Octylcyanoacrylate and n-butyl-2-cyanoacrylate. Type: Interventional Start Date: Jun 2022 |
Neural Connectivity During Therapy for Adolescent PTSD
The University of Texas Health Science Center at San Antonio
PTSD
Adolescent
Psychological Trauma
Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying
cognitive, social and emotional skills. Neuroimaging research that seeks to identify the
neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has
been slow using current methods1 expand
Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy. Type: Interventional Start Date: Nov 2022 |
Efficacy of the COronary SInus Reducer in Patients with Refractory Angina II
Shockwave Medical, Inc.
Refractory Angina
To demonstrate the safety and effectiveness of the Reducer system for treatment of
patients with refractory angina pectoris treated with maximally tolerated
guideline-directed medical therapy who demonstrate objective evidence of reversible
myocardial ischemia in the distribution of the left corona1 expand
To demonstrate the safety and effectiveness of the Reducer system for treatment of patients with refractory angina pectoris treated with maximally tolerated guideline-directed medical therapy who demonstrate objective evidence of reversible myocardial ischemia in the distribution of the left coronary artery and who are deemed unsuitable for revascularization. A non-randomized single-arm will further assess the safety and effectiveness of the Neovasc Reducer System in selected subjects with reversible myocardial ischemia in the distribution of the right coronary artery and who are deemed unsuitable for revascularization, subjects with reversible myocardial ischemia without documented obstructive coronary disease and subjects who cannot complete an exercise tolerance test due to an above-the-ankle amputation. Type: Interventional Start Date: Jan 2022 |
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TR1
Edison Leung
Bipolar Disorder
The purpose of this study is to compare the efficacy and side effects magnetic seizure
therapy (MST) and electroconvulsive therapy (ECT) in Bipolar Depression (MST-BpD) and
Treatment Resistant Depression (MST-TRD). expand
The purpose of this study is to compare the efficacy and side effects magnetic seizure therapy (MST) and electroconvulsive therapy (ECT) in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD). Type: Interventional Start Date: Mar 2025 |
Evaluation of Hemostasis in Bleeding and Thrombotic Disorders
The University of Texas Health Science Center, Houston
Blood Coagulation Disorders, Inherited
Thrombotic Disorder
The objective of this study will be to assess the coagulation system in-vitro in a
variety of bleeding and clotting disorders using the ROTEG analyzer and the thrombin
generation assay. expand
The objective of this study will be to assess the coagulation system in-vitro in a variety of bleeding and clotting disorders using the ROTEG analyzer and the thrombin generation assay. Type: Observational Start Date: Oct 2002 |
Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults with Neurogenic1
EG 427
Neurogenic Detrusor Overactivity
Spinal Cord Injuries
This is a first-in-human, Phase 1b/2a, open-label, dose-escalation study of a single
treatment course consisting of multiple intradetrusor injections of EG110A in male and
female adult participants with Neurogenic Detrusor Overactivity (NDO)-related
incontinence following Spinal Cord Injury (SCI),1 expand
This is a first-in-human, Phase 1b/2a, open-label, dose-escalation study of a single treatment course consisting of multiple intradetrusor injections of EG110A in male and female adult participants with Neurogenic Detrusor Overactivity (NDO)-related incontinence following Spinal Cord Injury (SCI), who have persistent incontinence after standard of care therapy and who perform Clear Intermittent Catheterization (CIC) on a regular basis. Type: Interventional Start Date: Jan 2025 |
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor
The University of Texas Health Science Center, Houston
Acute Kidney Injury
The purpose of this study is to determine whether perioperative intravenous
administration of pantoprazole will improve kidney function parameters following cardiac
surgery with cardiopulmonary bypass compared to famotidine and to determine whether
perioperative intravenous administration of pantop1 expand
The purpose of this study is to determine whether perioperative intravenous administration of pantoprazole will improve kidney function parameters following cardiac surgery with cardiopulmonary bypass compared to famotidine and to determine whether perioperative intravenous administration of pantoprazole will decrease the incidence of postoperative Acte Kidney Injury (AKI) and major adverse kidney events (MAKE). Type: Interventional Start Date: Jan 2024 |
A Study to Evaluate Long-term Safety of Ecopipam Tablets in Children, Adolescents and Adults With T1
Emalex Biosciences Inc.
Tourette Syndrome
The primary objective of this study is to evaluate the long-term safety and tolerability
of ecopipam tablets in children (greater than or equal to [>=] 6 and less than [<] 12
years of age), adolescents (>=12 and <18 years of age), and adults (>=18 years of age)
with Tourette's Syndrome (TS). expand
The primary objective of this study is to evaluate the long-term safety and tolerability of ecopipam tablets in children (greater than or equal to [>=] 6 and less than [<] 12 years of age), adolescents (>=12 and <18 years of age), and adults (>=18 years of age) with Tourette's Syndrome (TS). Type: Interventional Start Date: Aug 2023 |
Shoulder iD™ Primary Reversed Glenoid Outcomes Clinical Study
Stryker Trauma and Extremities
Rotator Cuff Tears
Rheumatoid Arthritis Shoulder
Osteoarthritis Shoulder
Avascular Necrosis of the Head of Humerus
Fracture, Humeral
The goal of the Shoulder iD™ Primary Reversed Glenoid Outcomes Clinical Study is to
collect safety and performance data on the commercially available Shoulder iD™ Primary
Reversed Glenoid device. The study will learn about standard device use in adult patients
who have a functional deltoid muscle a1 expand
The goal of the Shoulder iD™ Primary Reversed Glenoid Outcomes Clinical Study is to collect safety and performance data on the commercially available Shoulder iD™ Primary Reversed Glenoid device. The study will learn about standard device use in adult patients who have a functional deltoid muscle and massive and non-repairable rotator cuff tear. The main questions it aims to answer are: - What is the average improvement in patient-reported shoulder function after 2 years when compared to before the surgery, and - What is the rate of surgical revisions needed over a 10 year period Patients will be asked to will be asked to regularly attend their check-up visits with their surgeon (including having x-rays or CT images taken to check their shoulder and implant), to complete questionnaires to report how their shoulder is doing, and to tell their surgeon when they notice any changes. Type: Observational Start Date: Oct 2023 |
Millipede AspiRation for Revascularization in Stroke (MARRS) Study
Perfuze
Acute Ischemic Stroke
The objectives of the study are to examine the performance and safety characteristics of
the Millipede System when used for revascularization of patients with acute ischemic
stroke due to Large Vessel Occlusions (LVOs) and to record associated clinical outcomes. expand
The objectives of the study are to examine the performance and safety characteristics of the Millipede System when used for revascularization of patients with acute ischemic stroke due to Large Vessel Occlusions (LVOs) and to record associated clinical outcomes. Type: Interventional Start Date: Oct 2023 |
A Study of YL201 in Patients with Advanced Solid Tumors
MediLink Therapeutics (Suzhou) Co., Ltd.
Advanced Solid Tumor
This is a phase 1, multicenter, nonrandomized, open-label, first-in-human study of YL201
conducted in China and the United States. The study will include 2 parts: a dose
escalation part (Part 1) followed by a dose expansion part (Part 2).
Part 1 will estimate the MTD/RED(s) in dose escalation coho1 expand
This is a phase 1, multicenter, nonrandomized, open-label, first-in-human study of YL201 conducted in China and the United States. The study will include 2 parts: a dose escalation part (Part 1) followed by a dose expansion part (Part 2). Part 1 will estimate the MTD/RED(s) in dose escalation cohorts of patients with advanced solid tumors unresponsive to currently available therapies or for whom no standard therapy is available. Part 2 will include patients with selected advanced solid tumor types enrolled at the MTD/RED(s), to better define the safety profile and evaluate the efficacy of YL201. Type: Interventional Start Date: May 2022 |
Assessment of CCM in HF with Higher Ejection Fraction
Impulse Dynamics
Heart Failure
Heart Failure with Preserved Ejection Fraction
Heart Failure with Mid Range Ejection Fraction
Heart Failure with Moderately Reduced Ejection Fraction
Diastolic Heart Failure
The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac
Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and
≤60%. expand
The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤60%. Type: Interventional Start Date: Feb 2022 |
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Massachusetts General Hospital
Ischemic Stroke
Intracerebral Hemorrhage
Subarachnoid Hemorrhage
Dementia, Vascular
Mild Cognitive Impairment
The overall goal of the DISCOVERY study is to better understand what factors contribute
to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced
a stroke. The purpose of the study is to help doctors identify patients at risk for
dementia (decline in memory, thinking1 expand
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke" is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts). The investigators hypothesize that: 1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery. 2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke. 3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future. Type: Observational Start Date: Mar 2021 |
Couple-Based Meditation for Metastatic Lung Cancer Patients and Their Partners
M.D. Anderson Cancer Center
Lung Cancer
Objectives:
Our specific aims are to:
Aim 1: Examine the feasibility of a couple-based meditation program in 50 patients with
metastatic lung cancer and their partners.
Aim 2: Establish the initial efficacy of a couple-based meditation program in patients
and their partners regarding physical, p1 expand
Objectives: Our specific aims are to: Aim 1: Examine the feasibility of a couple-based meditation program in 50 patients with metastatic lung cancer and their partners. Aim 2: Establish the initial efficacy of a couple-based meditation program in patients and their partners regarding physical, psychological, and spiritual quality of life outcomes. Type: Interventional Start Date: Apr 2016 |
RECOVER-SLEEP: Platform Protocol
Duke University
Long COVID
Long COVID-19
Hypersomnia
Sleep Disturbance
The platform protocol is designed to be flexible so that it is suitable for a range of
study settings and intervention types. Therefore, the platform protocol provides a
general protocol structure that can be shared by multiple interventions and allows
comparative analysis across the interventions.1 expand
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple interventions and allows comparative analysis across the interventions. For example, objectives, measures, and endpoints are generalized in the platform protocol, but intervention-specific features are detailed in separate appendices. This platform protocol is a prospective, multi-center, multi-arm, randomized controlled platform trial evaluating potential interventions for PASC-mediated sleep disturbances. The hypothesis is that symptoms of sleep and circadian disorders that emerge in patients with PASC can be improved by phenotype-targeted interventions. Specific sleep and circadian disorders addressed in this protocol include sleep-related daytime impairment (referred to as hypersomnia) and complex PASC-related sleep disturbance (reflecting symptoms of insomnia and sleep-wake rhythm disturbance). Type: Interventional Start Date: Jul 2024 |
Study to Assess the Efficacy and Safety of Iovera®° System in Subjects with Upper Extremity Spastic1
Pacira Pharmaceuticals, Inc
Spasticity, Cerebral or Spinal Condition
This multicenter, randomized, double-blind, sham-controlled study is designed to evaluate
the efficacy and safety of the iovera° system in subjects with upper extremity
spasticity. A total of approximately 132 subjects will be enrolled; 88 subjects will
receive treatment with the iovera° system and1 expand
This multicenter, randomized, double-blind, sham-controlled study is designed to evaluate the efficacy and safety of the iovera° system in subjects with upper extremity spasticity. A total of approximately 132 subjects will be enrolled; 88 subjects will receive treatment with the iovera° system and 44 subjects will receive sham treatment (sham iovera° system treatment). Type: Interventional Start Date: Apr 2024 |
Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer
Novartis Pharmaceuticals
Prostate Cancer
The purpose of this post-marketing study is to further characterize the long-term outcome
of known or potential risks of lutetium (177Lu) vipivotide tetraxetan also known as
[177Lu]Lu-PSMA-617 or 177Lu-PSMA-617 and hereinafter referred to as AAA617. The study
also seeks to further characterize (as1 expand
The purpose of this post-marketing study is to further characterize the long-term outcome of known or potential risks of lutetium (177Lu) vipivotide tetraxetan also known as [177Lu]Lu-PSMA-617 or 177Lu-PSMA-617 and hereinafter referred to as AAA617. The study also seeks to further characterize (as possible) any other serious adverse reaction(s) in the long-term in adults with prostate cancer who received at least one dose of AAA617 from interventional, Phase I-IV Novartis sponsored clinical trials. Type: Interventional Start Date: Aug 2023 |
Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in He1
The University of Texas Health Science Center, Houston
Acute Kidney Injury
The investigators propose a single-center, randomized, controlled trial to determine
whether early initiation of proton pump inhibitor (PPI), pantoprazole, will decrease
acute kidney injury (AKI) for trauma patients presenting with hemorrhagic shock compared
to routine timing of initiation of PPI.1 expand
The investigators propose a single-center, randomized, controlled trial to determine whether early initiation of proton pump inhibitor (PPI), pantoprazole, will decrease acute kidney injury (AKI) for trauma patients presenting with hemorrhagic shock compared to routine timing of initiation of PPI. Kidney injury will be assessed by the urinary kidney injury biomarkers, and the incidence, severity and AKI-free days within first week and major adverse kidney events (MAKE) at day 30. The specific aims of the study will be achieved by a cohort of 100 patients to receive either early(study) or routine (control) administration of pantoprazole for 2 days after the initial injury insult. Type: Interventional Start Date: Sep 2024 |
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Zimmer Biomet
Knee Pain Chronic
Osteoarthritis, Knee
Rheumatoid Arthritis
Traumatic Arthritis
Polyarthritis
The main objective of the study is to evaluate the safety, performance and clinical
benefits of the Persona implant and its instrumentation in primary total knee
arthroplasty expand
The main objective of the study is to evaluate the safety, performance and clinical benefits of the Persona implant and its instrumentation in primary total knee arthroplasty Type: Observational Start Date: Jun 2023 |
Inspiring New Science In Guiding Healthcare in Turner Syndrome Registry
University of Colorado, Denver
Turner Syndrome
INSIGHTS is a registry research study that collects key information on medical history
for girls and women with Turner syndrome and the clinical care they receive. This
includes genetic tests, imaging, medications, and more for hundreds of patients seen at a
number of clinics across the US. In addi1 expand
INSIGHTS is a registry research study that collects key information on medical history for girls and women with Turner syndrome and the clinical care they receive. This includes genetic tests, imaging, medications, and more for hundreds of patients seen at a number of clinics across the US. In addition to learning a lot about the current state of health for individuals with TS, INSIGHTS serves as an infrastructure to conduct future studies are meaningful to patients and their families. Type: Observational [Patient Registry] Start Date: May 2020 |
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